Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 603817..604462 Replicon chromosome
Accession NZ_CP117825
Organism Fusobacterium nucleatum strain FNP

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PSC67_RS03165 Protein ID WP_274180693.1
Coordinates 603817..604185 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag PSC67_RS03170 Protein ID WP_274180694.1
Coordinates 604175..604462 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSC67_RS03145 (PSC67_03145) 600164..600670 - 507 WP_274180689.1 hypothetical protein -
PSC67_RS03150 (PSC67_03150) 600949..602124 + 1176 WP_274180690.1 IS110 family transposase -
PSC67_RS03155 (PSC67_03155) 602364..603485 + 1122 WP_274180691.1 hypothetical protein -
PSC67_RS03160 (PSC67_03160) 603518..603691 + 174 WP_274180692.1 hypothetical protein -
PSC67_RS03165 (PSC67_03165) 603817..604185 + 369 WP_274180693.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PSC67_RS03170 (PSC67_03170) 604175..604462 + 288 WP_274180694.1 helix-turn-helix transcriptional regulator Antitoxin
PSC67_RS03175 (PSC67_03175) 604485..604805 + 321 WP_274180695.1 nucleotidyltransferase domain-containing protein -
PSC67_RS03180 (PSC67_03180) 604798..605187 + 390 WP_098979686.1 DUF86 domain-containing protein -
PSC67_RS03185 (PSC67_03185) 605205..605504 + 300 WP_274180696.1 STAS-like domain-containing protein -
PSC67_RS03190 (PSC67_03190) 605554..605874 + 321 WP_098979687.1 nucleotidyltransferase domain-containing protein -
PSC67_RS03195 (PSC67_03195) 605939..606157 + 219 WP_274180697.1 DUF6290 family protein -
PSC67_RS03200 (PSC67_03200) 606197..606739 - 543 WP_274180698.1 hypothetical protein -
PSC67_RS03205 (PSC67_03205) 606766..607272 - 507 WP_274180699.1 HAD family hydrolase -
PSC67_RS03210 (PSC67_03210) 607282..607854 - 573 WP_274180700.1 crossover junction endodeoxyribonuclease RuvC -
PSC67_RS03215 (PSC67_03215) 607854..608606 - 753 WP_032847258.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-89)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14781.33 Da        Isoelectric Point: 10.3677

>T272324 WP_274180693.1 NZ_CP117825:603817-604185 [Fusobacterium nucleatum]
MYKVGFYLKNGKSDIIEYLDKLKIKSEKSKEARIIRNKILSYIKSLELYGTRVGEPIVKHIEDDIWELRPLNNRIFFFYF
KDNKFILLHYFIKKTNKTPKKEIEEARNRMNDFIARSDKNVK

Download         Length: 369 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10962.84 Da        Isoelectric Point: 5.1767

>AT272324 WP_274180694.1 NZ_CP117825:604175-604462 [Fusobacterium nucleatum]
MSNNEYLDFDDYFNDETKVSKEDKAIIELETLLIGKMIEIREKKGLTQRQLAELIGMKQPAIARLEKLQTIPHLTTLIKF
LTPLGYKLSIVPIEN

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References