Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2528754..2529365 Replicon chromosome
Accession NZ_CP117823
Organism Xylella fastidiosa strain ICMP 8742

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag PUO95_RS11450 Protein ID WP_011098375.1
Coordinates 2529066..2529365 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag PUO95_RS11445 Protein ID WP_004085003.1
Coordinates 2528754..2529062 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO95_RS11415 (PUO95_11415) 2525324..2526085 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
PUO95_RS11440 (PUO95_11440) 2527277..2528680 + 1404 WP_274265325.1 hypothetical protein -
PUO95_RS11445 (PUO95_11445) 2528754..2529062 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
PUO95_RS11450 (PUO95_11450) 2529066..2529365 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PUO95_RS11455 (PUO95_11455) 2529453..2529986 + 534 WP_225621759.1 hypothetical protein -
PUO95_RS11460 (PUO95_11460) 2530009..2530152 + 144 WP_155115087.1 hypothetical protein -
PUO95_RS11465 (PUO95_11465) 2530305..2530685 - 381 WP_004089371.1 DUF596 domain-containing protein -
PUO95_RS11470 (PUO95_11470) 2530690..2531820 - 1131 WP_012382788.1 DUF769 domain-containing protein -
PUO95_RS11475 (PUO95_11475) 2532128..2532508 - 381 WP_004087391.1 DUF596 domain-containing protein -
PUO95_RS11480 (PUO95_11480) 2532520..2533881 - 1362 WP_272819646.1 hemagglutinin -
PUO95_RS11485 (PUO95_11485) 2533961..2534104 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2479626..2529815 50189


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T272320 WP_011098375.1 NZ_CP117823:c2529365-2529066 [Xylella fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT272320 WP_004085003.1 NZ_CP117823:c2529062-2528754 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References