Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2019837..2020368 Replicon chromosome
Accession NZ_CP117823
Organism Xylella fastidiosa strain ICMP 8742

Toxin (Protein)


Gene name relE Uniprot ID Q87CH1
Locus tag PUO95_RS09225 Protein ID WP_004090909.1
Coordinates 2020087..2020368 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q87CH2
Locus tag PUO95_RS09220 Protein ID WP_004090907.1
Coordinates 2019837..2020100 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PUO95_RS09195 (PUO95_09195) 2015063..2016241 - 1179 WP_128734780.1 phage tail sheath family protein -
PUO95_RS09200 (PUO95_09200) 2016306..2017898 - 1593 WP_159241645.1 hypothetical protein -
PUO95_RS09205 (PUO95_09205) 2017906..2018463 - 558 WP_004086970.1 phage tail protein I -
PUO95_RS09210 (PUO95_09210) 2018456..2019349 - 894 WP_011097611.1 baseplate J/gp47 family protein -
PUO95_RS09215 (PUO95_09215) 2019349..2019711 - 363 WP_014607615.1 GPW/gp25 family protein -
PUO95_RS09220 (PUO95_09220) 2019837..2020100 + 264 WP_004090907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PUO95_RS09225 (PUO95_09225) 2020087..2020368 + 282 WP_004090909.1 type II toxin-antitoxin system YafQ family toxin Toxin
PUO95_RS09230 (PUO95_09230) 2020405..2020992 - 588 WP_011097612.1 phage baseplate assembly protein V -
PUO95_RS09235 (PUO95_09235) 2020989..2021531 - 543 WP_011097613.1 hypothetical protein -
PUO95_RS09240 (PUO95_09240) 2021507..2022028 - 522 WP_011097614.1 hypothetical protein -
PUO95_RS09245 (PUO95_09245) 2022025..2022348 - 324 WP_011097935.1 hypothetical protein -
PUO95_RS09250 (PUO95_09250) 2022348..2022608 - 261 WP_038232801.1 hypothetical protein -
PUO95_RS09255 (PUO95_09255) 2022626..2024500 - 1875 WP_038232803.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2006424..2073093 66669


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10936.37 Da        Isoelectric Point: 7.2205

>T272319 WP_004090909.1 NZ_CP117823:2020087-2020368 [Xylella fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9495.95 Da        Isoelectric Point: 5.6033

>AT272319 WP_004090907.1 NZ_CP117823:2019837-2020100 [Xylella fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87CH1

Antitoxin

Source ID Structure
AlphaFold DB Q87CH2

References