Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2381644..2382255 Replicon chromosome
Accession NZ_CP117821
Organism Xylella fastidiosa strain ICMP 8731

Toxin (Protein)


Gene name relE Uniprot ID Q879T9
Locus tag PT013_RS10575 Protein ID WP_011098375.1
Coordinates 2381956..2382255 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q879U0
Locus tag PT013_RS10570 Protein ID WP_004085003.1
Coordinates 2381644..2381952 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT013_RS10540 (PT013_10540) 2378214..2378975 - 762 WP_004090267.1 Bax inhibitor-1/YccA family protein -
PT013_RS10565 (PT013_10565) 2380167..2381570 + 1404 WP_274205386.1 hypothetical protein -
PT013_RS10570 (PT013_10570) 2381644..2381952 - 309 WP_004085003.1 putative addiction module antidote protein Antitoxin
PT013_RS10575 (PT013_10575) 2381956..2382255 - 300 WP_011098375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT013_RS10580 (PT013_10580) 2382310..2382888 + 579 WP_014607536.1 hypothetical protein -
PT013_RS10585 (PT013_10585) 2382900..2383043 + 144 WP_155115087.1 hypothetical protein -
PT013_RS10590 (PT013_10590) 2383196..2383576 - 381 WP_004089371.1 DUF596 domain-containing protein -
PT013_RS10595 (PT013_10595) 2383581..2384711 - 1131 WP_012382788.1 DUF769 domain-containing protein -
PT013_RS10600 (PT013_10600) 2385019..2385399 - 381 WP_004087391.1 DUF596 domain-containing protein -
PT013_RS10605 (PT013_10605) 2385411..2386772 - 1362 WP_272819646.1 hemagglutinin -
PT013_RS10610 (PT013_10610) 2386852..2386995 + 144 WP_155115088.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2332419..2382705 50286


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-98)

Antitoxin

Uncharacterized protein HI1420

(15-100)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11378.17 Da        Isoelectric Point: 10.3861

>T272311 WP_011098375.1 NZ_CP117821:c2382255-2381956 [Xylella fastidiosa]
MTYTLKRLEGFSDWLKGLKDGLARQRLIKRLRKVQLGNFGDVQPVGEGVFEMREHFGPGWRMYYVQRGSFLIVMLGGGDK
STQQSDIRRAIELAKSLED

Download         Length: 300 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11060.61 Da        Isoelectric Point: 4.6535

>AT272311 WP_004085003.1 NZ_CP117821:c2381952-2381644 [Xylella fastidiosa]
VTITKKINVSELPEFDAAEYLNSEEEVAAYLTAVLEENDPALLAAALGDIARSRGMSQIAKDSGITREALYKALRPGSEP
RFDTISRVCTALGIRLVAQPMH

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q879T9

Antitoxin

Source ID Structure
AlphaFold DB A0A060HCD4

References