Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 1194766..1195297 Replicon chromosome
Accession NZ_CP117821
Organism Xylella fastidiosa strain ICMP 8731

Toxin (Protein)


Gene name relE Uniprot ID Q87CH1
Locus tag PT013_RS05340 Protein ID WP_004090909.1
Coordinates 1195016..1195297 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID Q87CH2
Locus tag PT013_RS05335 Protein ID WP_004090907.1
Coordinates 1194766..1195029 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT013_RS05310 (PT013_05310) 1189992..1191170 - 1179 WP_011097931.1 phage tail sheath family protein -
PT013_RS05315 (PT013_05315) 1191235..1192827 - 1593 WP_012382617.1 tail fiber domain-containing protein -
PT013_RS05320 (PT013_05320) 1192835..1193392 - 558 WP_011097610.1 phage tail protein I -
PT013_RS05325 (PT013_05325) 1193385..1194278 - 894 WP_011097611.1 baseplate J/gp47 family protein -
PT013_RS05330 (PT013_05330) 1194278..1194640 - 363 WP_014607615.1 GPW/gp25 family protein -
PT013_RS05335 (PT013_05335) 1194766..1195029 + 264 WP_004090907.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PT013_RS05340 (PT013_05340) 1195016..1195297 + 282 WP_004090909.1 type II toxin-antitoxin system YafQ family toxin Toxin
PT013_RS05345 (PT013_05345) 1195334..1195921 - 588 WP_011097612.1 phage baseplate assembly protein V -
PT013_RS05350 (PT013_05350) 1195918..1196460 - 543 WP_011097613.1 hypothetical protein -
PT013_RS05355 (PT013_05355) 1196436..1196957 - 522 WP_011097614.1 hypothetical protein -
PT013_RS05360 (PT013_05360) 1196954..1197277 - 324 WP_012382618.1 hypothetical protein -
PT013_RS05365 (PT013_05365) 1197277..1197537 - 261 WP_012382619.1 hypothetical protein -
PT013_RS05370 (PT013_05370) 1197555..1199429 - 1875 WP_012382620.1 phage major capsid protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1181353..1228075 46722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10936.37 Da        Isoelectric Point: 7.2205

>T272307 WP_004090909.1 NZ_CP117821:1195016-1195297 [Xylella fastidiosa]
MRRISQTGQFKRDYKREAKGQHRATLDEELIHVLEALTCDHPLEPRHHDHALTGDWKDHRDCHIKPDLVLIYRKPDNETL
QLVRIGSHSELGL

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9495.95 Da        Isoelectric Point: 5.6033

>AT272307 WP_004090907.1 NZ_CP117821:1194766-1195029 [Xylella fastidiosa]
MSANAVVRARVDAHIKEEASTVLATMGLSVSDAFRMMLTRIAREKALPFEPLVPNETTIAAMREARAGHLKSFDSIEALM
ADLHAED

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q87CH1

Antitoxin

Source ID Structure
AlphaFold DB Q87CH2

References