Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1861379..1861971 Replicon chromosome
Accession NZ_CP117820
Organism Xylella fastidiosa strain ICMP 8740

Toxin (Protein)


Gene name PumA Uniprot ID A0A060HCK8
Locus tag PT012_RS08515 Protein ID WP_004085590.1
Coordinates 1861379..1861675 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PT012_RS08520 Protein ID WP_004085592.1
Coordinates 1861678..1861971 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT012_RS08495 (PT012_08495) 1856898..1857902 - 1005 WP_027700600.1 peptidase -
PT012_RS08500 (PT012_08500) 1858407..1859570 - 1164 WP_274169883.1 phage tail protein -
PT012_RS08505 (PT012_08505) 1859574..1860134 - 561 WP_027700634.1 DUF2612 domain-containing protein -
PT012_RS08510 (PT012_08510) 1860131..1861276 - 1146 WP_027700633.1 baseplate J/gp47 family protein -
PT012_RS08515 (PT012_08515) 1861379..1861675 + 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT012_RS08520 (PT012_08520) 1861678..1861971 + 294 WP_004085592.1 putative addiction module antidote protein Antitoxin
PT012_RS08525 (PT012_08525) 1862027..1862380 - 354 WP_027700632.1 hypothetical protein -
PT012_RS08530 (PT012_08530) 1862377..1863018 - 642 WP_012382583.1 Gp138 family membrane-puncturing spike protein -
PT012_RS08535 (PT012_08535) 1863015..1863845 - 831 WP_027700631.1 hypothetical protein -
PT012_RS08540 (PT012_08540) 1863842..1864159 - 318 WP_012382585.1 hypothetical protein -
PT012_RS08545 (PT012_08545) 1864159..1864929 - 771 WP_272819576.1 hypothetical protein -
PT012_RS08550 (PT012_08550) 1865282..1865536 - 255 WP_027700683.1 Blp family class II bacteriocin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1850640..1907733 57093


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11169.70 Da        Isoelectric Point: 10.0610

>T272300 WP_004085590.1 NZ_CP117820:1861379-1861675 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE

Download         Length: 297 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10246.59 Da        Isoelectric Point: 5.6232

>AT272300 WP_004085592.1 NZ_CP117820:1861678-1861971 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HCK8

Antitoxin

Source ID Structure

References