Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 1378558..1379150 Replicon chromosome
Accession NZ_CP117820
Organism Xylella fastidiosa strain ICMP 8740

Toxin (Protein)


Gene name PumA Uniprot ID A0A060HCK8
Locus tag PT012_RS06210 Protein ID WP_004085590.1
Coordinates 1378558..1378854 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PT012_RS06215 Protein ID WP_004085592.1
Coordinates 1378857..1379150 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT012_RS06190 (PT012_06190) 1374077..1375081 - 1005 WP_027700600.1 peptidase -
PT012_RS06195 (PT012_06195) 1375586..1376749 - 1164 WP_274169883.1 phage tail protein -
PT012_RS06200 (PT012_06200) 1376753..1377313 - 561 WP_027700634.1 DUF2612 domain-containing protein -
PT012_RS06205 (PT012_06205) 1377310..1378455 - 1146 WP_027700633.1 baseplate J/gp47 family protein -
PT012_RS06210 (PT012_06210) 1378558..1378854 + 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT012_RS06215 (PT012_06215) 1378857..1379150 + 294 WP_004085592.1 putative addiction module antidote protein Antitoxin
PT012_RS06220 (PT012_06220) 1379206..1379559 - 354 WP_027700632.1 hypothetical protein -
PT012_RS06225 (PT012_06225) 1379556..1380197 - 642 WP_012382583.1 Gp138 family membrane-puncturing spike protein -
PT012_RS06230 (PT012_06230) 1380194..1381024 - 831 WP_027700631.1 hypothetical protein -
PT012_RS06235 (PT012_06235) 1381021..1381338 - 318 WP_012382585.1 hypothetical protein -
PT012_RS06240 (PT012_06240) 1381338..1382108 - 771 WP_274169884.1 hypothetical protein -
PT012_RS06245 (PT012_06245) 1382219..1382446 + 228 WP_004091377.1 DUF6290 family protein -
PT012_RS06250 (PT012_06250) 1382430..1382696 + 267 WP_004087087.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1351620..1395547 43927


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11169.70 Da        Isoelectric Point: 10.0610

>T272297 WP_004085590.1 NZ_CP117820:1378558-1378854 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE

Download         Length: 297 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10246.59 Da        Isoelectric Point: 5.6232

>AT272297 WP_004085592.1 NZ_CP117820:1378857-1379150 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HCK8

Antitoxin

Source ID Structure

References