Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 889108..889649 Replicon chromosome
Accession NZ_CP117820
Organism Xylella fastidiosa strain ICMP 8740

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PT012_RS04090 Protein ID WP_027700637.1
Coordinates 889108..889431 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PT012_RS04095 Protein ID WP_027700636.1
Coordinates 889428..889649 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT012_RS04055 (PT012_04055) 884254..884460 + 207 WP_071870022.1 hypothetical protein -
PT012_RS04060 (PT012_04060) 884469..884693 + 225 WP_038284180.1 major capsid protein -
PT012_RS04065 (PT012_04065) 884772..886220 + 1449 WP_155238085.1 virulence factor TspB C-terminal domain-related protein -
PT012_RS04070 (PT012_04070) 886224..886565 + 342 WP_027700640.1 DUF2523 family protein -
PT012_RS04075 (PT012_04075) 886565..887698 + 1134 WP_080654478.1 zonular occludens toxin domain-containing protein -
PT012_RS04080 (PT012_04080) 887713..887982 - 270 WP_027700639.1 septation ring formation regulator EzrA -
PT012_RS04085 (PT012_04085) 888244..889074 + 831 WP_027700638.1 site-specific integrase -
PT012_RS04090 (PT012_04090) 889108..889431 - 324 WP_027700637.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PT012_RS04095 (PT012_04095) 889428..889649 - 222 WP_027700636.1 antitoxin MazE family protein Antitoxin
PT012_RS04100 (PT012_04100) 889825..890085 - 261 WP_247644640.1 DUF3693 domain-containing protein -
PT012_RS04105 (PT012_04105) 890383..891027 - 645 WP_004085407.1 histidine phosphatase family protein -
PT012_RS04110 (PT012_04110) 891114..893189 - 2076 WP_027700727.1 S46 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-103)

Antitoxin

Antitoxin MazE-like

(9-72)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11799.86 Da        Isoelectric Point: 7.9848

>T272295 WP_027700637.1 NZ_CP117820:c889431-889108 [Xylella fastidiosa]
MIQRGDLVTVSLQGDYGKPRPALIVQSDLLTELDSVVLCPVTSDLRNAIFRVTVEPTAANGLRTLSQVMVDKISTLPRNK
ISEPFGRLNDERMKAIERALLLIIGII

Download         Length: 324 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8458.64 Da        Isoelectric Point: 9.3510

>AT272295 WP_027700636.1 NZ_CP117820:c889649-889428 [Xylella fastidiosa]
MTSTHRPDSKIVHHREQMRAAGLRPMQLWVPDTRTPEFAAEIRSQCRALKGDQAEADALRFTEKTMTHIEGWK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References