Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 742268..742860 Replicon chromosome
Accession NZ_CP117820
Organism Xylella fastidiosa strain ICMP 8740

Toxin (Protein)


Gene name PumA Uniprot ID A0A060HCK8
Locus tag PT012_RS03365 Protein ID WP_004085590.1
Coordinates 742564..742860 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PT012_RS03360 Protein ID WP_004085592.1
Coordinates 742268..742561 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT012_RS03325 (PT012_03325) 738722..738988 - 267 WP_004087087.1 type II toxin-antitoxin system RelE/ParE family toxin -
PT012_RS03330 (PT012_03330) 738972..739199 - 228 WP_004091377.1 DUF6290 family protein -
PT012_RS03335 (PT012_03335) 739310..740080 + 771 WP_274169884.1 hypothetical protein -
PT012_RS03340 (PT012_03340) 740080..740397 + 318 WP_012382585.1 hypothetical protein -
PT012_RS03345 (PT012_03345) 740394..741224 + 831 WP_027700631.1 hypothetical protein -
PT012_RS03350 (PT012_03350) 741221..741862 + 642 WP_012382583.1 Gp138 family membrane-puncturing spike protein -
PT012_RS03355 (PT012_03355) 741859..742212 + 354 WP_027700632.1 hypothetical protein -
PT012_RS03360 (PT012_03360) 742268..742561 - 294 WP_004085592.1 putative addiction module antidote protein Antitoxin
PT012_RS03365 (PT012_03365) 742564..742860 - 297 WP_004085590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PT012_RS03370 (PT012_03370) 742963..744108 + 1146 WP_027700633.1 baseplate J/gp47 family protein -
PT012_RS03375 (PT012_03375) 744105..744665 + 561 WP_027700634.1 DUF2612 domain-containing protein -
PT012_RS03380 (PT012_03380) 744669..745913 + 1245 WP_272819575.1 phage tail protein -
PT012_RS03385 (PT012_03385) 746017..746463 - 447 WP_004084994.1 hypothetical protein -
PT012_RS03390 (PT012_03390) 746721..747689 - 969 WP_004084992.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 701573..745913 44340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-94)

Antitoxin

Uncharacterized protein HI1420

(3-93)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11169.70 Da        Isoelectric Point: 10.0610

>T272294 WP_004085590.1 NZ_CP117820:c742860-742564 [Xylella fastidiosa]
MIELKQTDTFRKWREKLKDARARSAIASRLDRLAFGHVGDAEPVGKGVSELRINYGPGYRVYFQRRGDTIYLLLCGGDKG
SQARDIKTALHLSEQWSE

Download         Length: 297 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10246.59 Da        Isoelectric Point: 5.6232

>AT272294 WP_004085592.1 NZ_CP117820:c742561-742268 [Xylella fastidiosa]
MTEKLTSYDPAEDLTTDQAIADFMAAAFGTNDPAYVAHALGVVARAKGMTQIASQTGLSREQLYRSFSAEGNPTLRTTLA
VMKALGIELSAKPSGVH

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060HCK8

Antitoxin

Source ID Structure

References