Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 19257..19855 Replicon plasmid unnamed
Accession NZ_CP117816
Organism Legionella pneumophila strain D5573

Toxin (Protein)


Gene name hicA Uniprot ID Q5WRX3
Locus tag PT256_RS00085 Protein ID WP_011212625.1
Coordinates 19658..19855 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q5WRX4
Locus tag PT256_RS00080 Protein ID WP_011212624.1
Coordinates 19257..19661 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT256_RS00070 (PT256_00070) 14925..15497 - 573 WP_059411244.1 recombinase family protein -
PT256_RS00075 (PT256_00075) 15633..18638 + 3006 WP_059411246.1 Tn3 family transposase -
PT256_RS00080 (PT256_00080) 19257..19661 - 405 WP_011212624.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PT256_RS00085 (PT256_00085) 19658..19855 - 198 WP_011212625.1 type II toxin-antitoxin system HicA family toxin Toxin
PT256_RS00090 (PT256_00090) 20727..21590 - 864 WP_052358007.1 zincin-like metallopeptidase domain-containing protein -
PT256_RS00095 (PT256_00095) 21900..22061 - 162 WP_011212628.1 hypothetical protein -
PT256_RS00100 (PT256_00100) 22634..23167 - 534 WP_011212629.1 glyoxalase superfamily protein -
PT256_RS00105 (PT256_00105) 23747..24724 + 978 WP_230305538.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..56207 56207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7403.75 Da        Isoelectric Point: 10.6519

>T272286 WP_011212625.1 NZ_CP117816:c19855-19658 [Legionella pneumophila]
MKSAEIIKIIERDGWVQCHQKGSHCQFKHPTKKGRVTVPHPKKDLPIKTVASIFKQAGINKEDIK

Download         Length: 198 bp

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15006.00 Da        Isoelectric Point: 4.5129

>AT272286 WP_011212624.1 NZ_CP117816:c19661-19257 [Legionella pneumophila]
MRYPVVIHKDEHSDFGVIVPDIPGCYSSGSTYDEALTNVIEAIECHLEGLLIDNEPLPVGTTIDRWINDEEFQGGVWAFV
DIDLSQISGKAKRINITMPERILSLIDLYAKNHAIKNRSSFLADAALSYMESHK

Download         Length: 405 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0VJ23

Antitoxin

Source ID Structure
AlphaFold DB Q5WRX4

References