Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4186223..4187794 Replicon chromosome
Accession NZ_CP117798
Organism Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PT008_RS19730 Protein ID WP_098941509.1
Coordinates 4186223..4187536 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PT008_RS19735 Protein ID WP_072070485.1
Coordinates 4187537..4187794 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT008_RS19710 (PT008_19710) 4181711..4183792 + 2082 WP_098941513.1 TonB-dependent receptor -
PT008_RS19715 (PT008_19715) 4183873..4184652 + 780 WP_098941512.1 ABC transporter ATP-binding protein -
PT008_RS19720 (PT008_19720) 4184753..4185214 - 462 WP_098941511.1 DUF1097 domain-containing protein -
PT008_RS19725 (PT008_19725) 4185847..4186026 - 180 WP_088494147.1 hypothetical protein -
PT008_RS19730 (PT008_19730) 4186223..4187536 - 1314 WP_098941509.1 type II toxin-antitoxin system HipA family toxin Toxin
PT008_RS19735 (PT008_19735) 4187537..4187794 - 258 WP_072070485.1 helix-turn-helix domain-containing protein Antitoxin
PT008_RS19740 (PT008_19740) 4187943..4189307 - 1365 WP_023583363.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
PT008_RS19745 (PT008_19745) 4189438..4191078 - 1641 WP_098941508.1 membrane protein insertase YidC -
PT008_RS19750 (PT008_19750) 4191081..4191341 - 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
PT008_RS19755 (PT008_19755) 4191305..4191475 - 171 Protein_3875 ribonuclease P protein component -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49636.50 Da        Isoelectric Point: 5.8274

>T272277 WP_098941509.1 NZ_CP117798:c4187536-4186223 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYAEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNPEIRNRIVSRYN
ANSNQPFDLLTAVGADTVGALRLLPSSSTPANIKKIEYNKLDNAELEKILLGYQSNTPLGMLEEYTDFRISIAGAQEKTA
LLLKDDHWCVPHNNTPTTHIIKLPIGVIEGHSYTMDLSDSVENEYLCTLIAKEFDLPVPHCFIVKTENIKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMNYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLQASRGKKYAIEQIFPRHFYQTAEAASFDPSLMTDILRYFYKEM
DDAIKRVKQQLPDDFPSEISSKILNGMKTRSARLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9848.40 Da        Isoelectric Point: 10.0139

>AT272277 WP_072070485.1 NZ_CP117798:c4187794-4187537 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQGKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References