Detailed information of TA system TA272275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3421745..3423492
• Replicon: chromosome
• Accession: NZ_CP117798
• Organism: Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: PT008_RS16335
• Protein ID: WP_098941872.1
• Coordinates: 3421745..3423118 (+)
• Length: 458 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PT008_RS16340
• Protein ID: WP_098941871.1
• Coordinates: 3423115..3423492 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PT008_RS16320 (PT008_16320)	3417735..3418376	-	642	Protein_3192	ABC transporter permease	-
PT008_RS16325 (PT008_16325)	3418376..3419959	-	1584	WP_098941874.1	ABC transporter substrate-binding protein	-
PT008_RS16330 (PT008_16330)	3420373..3421362	-	990	WP_098941873.1	glycosyltransferase	-
PT008_RS16335 (PT008_16335)	3421745..3423118	+	1374	WP_098941872.1	HipA domain-containing protein	Toxin
PT008_RS16340 (PT008_16340)	3423115..3423492	+	378	WP_098941871.1	helix-turn-helix transcriptional regulator	Antitoxin
PT008_RS16345 (PT008_16345)	3423614..3424114	-	501	WP_109850427.1	hydrogenase maturation peptidase HycI	-
PT008_RS16350 (PT008_16350)	3424111..3424521	-	411	WP_075673443.1	formate hydrogenlyase maturation HycH family protein	-
PT008_RS16355 (PT008_16355)	3424514..3425296	-	783	WP_277697998.1	NADH-quinone oxidoreductase subunit B family protein	-
PT008_RS16360 (PT008_16360)	3425293..3425847	-	555	WP_075673442.1	hydrogenase 4 subunit H	-
PT008_RS16365 (PT008_16365)	3425859..3427592	-	1734	WP_075673441.1	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-418)

Antitoxin

• Cro/C1-type helix-turn-helix domain (48-103)

Sequences

Toxin

Protein

• Length: 458 a.a.
• Molecular weight: 52589.44 Da
• Isoelectric Point: 4.6415

>T272275 WP_098941872.1 NZ_CP117798:3421745-3423118 [Proteus mirabilis]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Nucleotide

• Length: 1374 bp

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14108.43 Da
• Isoelectric Point: 10.5220

>AT272275 WP_098941871.1 NZ_CP117798:3423115-3423492 [Proteus mirabilis]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Nucleotide

• Length: 378 bp