Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3421745..3423492 Replicon chromosome
Accession NZ_CP117798
Organism Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PT008_RS16335 Protein ID WP_098941872.1
Coordinates 3421745..3423118 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PT008_RS16340 Protein ID WP_098941871.1
Coordinates 3423115..3423492 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT008_RS16320 (PT008_16320) 3417735..3418376 - 642 Protein_3192 ABC transporter permease -
PT008_RS16325 (PT008_16325) 3418376..3419959 - 1584 WP_098941874.1 ABC transporter substrate-binding protein -
PT008_RS16330 (PT008_16330) 3420373..3421362 - 990 WP_098941873.1 glycosyltransferase -
PT008_RS16335 (PT008_16335) 3421745..3423118 + 1374 WP_098941872.1 HipA domain-containing protein Toxin
PT008_RS16340 (PT008_16340) 3423115..3423492 + 378 WP_098941871.1 helix-turn-helix transcriptional regulator Antitoxin
PT008_RS16345 (PT008_16345) 3423614..3424114 - 501 WP_109850427.1 hydrogenase maturation peptidase HycI -
PT008_RS16350 (PT008_16350) 3424111..3424521 - 411 WP_075673443.1 formate hydrogenlyase maturation HycH family protein -
PT008_RS16355 (PT008_16355) 3424514..3425296 - 783 WP_277697998.1 NADH-quinone oxidoreductase subunit B family protein -
PT008_RS16360 (PT008_16360) 3425293..3425847 - 555 WP_075673442.1 hydrogenase 4 subunit H -
PT008_RS16365 (PT008_16365) 3425859..3427592 - 1734 WP_075673441.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T272275 WP_098941872.1 NZ_CP117798:3421745-3423118 [Proteus mirabilis]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14108.43 Da        Isoelectric Point: 10.5220

>AT272275 WP_098941871.1 NZ_CP117798:3423115-3423492 [Proteus mirabilis]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References