Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3406887..3408616 Replicon chromosome
Accession NZ_CP117798
Organism Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PT008_RS16265 Protein ID WP_196731066.1
Coordinates 3406887..3408257 (+) Length 457 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PT008_RS16270 Protein ID WP_060556489.1
Coordinates 3408254..3408616 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT008_RS16250 (PT008_16250) 3402548..3403531 - 984 WP_060556493.1 ABC transporter permease -
PT008_RS16255 (PT008_16255) 3403516..3405099 - 1584 WP_107034445.1 ABC transporter substrate-binding protein -
PT008_RS16260 (PT008_16260) 3405500..3406492 - 993 WP_060556491.1 glycosyltransferase -
PT008_RS16265 (PT008_16265) 3406887..3408257 + 1371 WP_196731066.1 HipA domain-containing protein Toxin
PT008_RS16270 (PT008_16270) 3408254..3408616 + 363 WP_060556489.1 helix-turn-helix transcriptional regulator Antitoxin
PT008_RS16275 (PT008_16275) 3408756..3409256 - 501 WP_004245684.1 hydrogenase maturation peptidase HycI -
PT008_RS16280 (PT008_16280) 3409253..3409663 - 411 WP_004245685.1 formate hydrogenlyase maturation HycH family protein -
PT008_RS16285 (PT008_16285) 3409656..3410438 - 783 WP_060556488.1 NADH-quinone oxidoreductase subunit B family protein -
PT008_RS16290 (PT008_16290) 3410435..3410989 - 555 WP_004245688.1 hydrogenase 4 subunit H -
PT008_RS16295 (PT008_16295) 3411001..3412816 - 1816 Protein_3187 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-415)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-101)


Sequences

Toxin        


Download         Length: 457 a.a.        Molecular weight: 52533.44 Da        Isoelectric Point: 4.7859

>T272274 WP_196731066.1 NZ_CP117798:3406887-3408257 [Proteus mirabilis]
MEKITLQAFLNQEWRDIAIINFPNDEHLALENQYDITYPITELAYESDYSIDYLFRDDHHAVSLNHPVSLFFDDKGSPGW
CKFLDDIVPSGASRRYWVQYLDIAGLSIAQQNYQLLRHGTISPIGNLRVKESLPHLSTLNNDLFFTIDEVKNRSSDFLEY
AQRKGAAAGGATGAGGEAPKLLLRCSHDEKIWIDTYQNDISNHDRYYLVKFPRGRRTSVDCNILRTEYAFYHELTAMGFN
TIPIEGMRLEEGDNYPSLWLPRFDIQIENNQVIRLAMESVYSILNKASGTTLYHEAVIREIIEKINQSNMVTEFGFQFNI
TNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRKDNAIYLAPIYDFAPMKADPEGIVRTTKWQSYEMGGEFDFIGIANSLAD
LIPQEQLLEALRETALQLLDLKERLKERGVPEQILTMPTFGFDFIPDKLARWGLLP

Download         Length: 1371 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13542.07 Da        Isoelectric Point: 10.6882

>AT272274 WP_060556489.1 NZ_CP117798:3408254-3408616 [Proteus mirabilis]
MNNIDNKITKLPLRASNNRSLIATIDRKKTIEKIMLSLLLEEISQGKALKILRLNILGLKQDAYAKLVNISRKTLSDIEN
DKGNYSIDIINKAFKPFGLKIGLVPATSHMLLSILKNHYQ

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References