Detailed information of TA system TA272274

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3406887..3408616
• Replicon: chromosome
• Accession: NZ_CP117798
• Organism: Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: PT008_RS16265
• Protein ID: WP_196731066.1
• Coordinates: 3406887..3408257 (+)
• Length: 457 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: PT008_RS16270
• Protein ID: WP_060556489.1
• Coordinates: 3408254..3408616 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PT008_RS16250 (PT008_16250)	3402548..3403531	-	984	WP_060556493.1	ABC transporter permease	-
PT008_RS16255 (PT008_16255)	3403516..3405099	-	1584	WP_107034445.1	ABC transporter substrate-binding protein	-
PT008_RS16260 (PT008_16260)	3405500..3406492	-	993	WP_060556491.1	glycosyltransferase	-
PT008_RS16265 (PT008_16265)	3406887..3408257	+	1371	WP_196731066.1	HipA domain-containing protein	Toxin
PT008_RS16270 (PT008_16270)	3408254..3408616	+	363	WP_060556489.1	helix-turn-helix transcriptional regulator	Antitoxin
PT008_RS16275 (PT008_16275)	3408756..3409256	-	501	WP_004245684.1	hydrogenase maturation peptidase HycI	-
PT008_RS16280 (PT008_16280)	3409253..3409663	-	411	WP_004245685.1	formate hydrogenlyase maturation HycH family protein	-
PT008_RS16285 (PT008_16285)	3409656..3410438	-	783	WP_060556488.1	NADH-quinone oxidoreductase subunit B family protein	-
PT008_RS16290 (PT008_16290)	3410435..3410989	-	555	WP_004245688.1	hydrogenase 4 subunit H	-
PT008_RS16295 (PT008_16295)	3411001..3412816	-	1816	Protein_3187	hydrogenase large subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (174-415)

Antitoxin

• Cro/C1-type helix-turn-helix domain (46-101)

Sequences

Toxin

Protein

• Length: 457 a.a.
• Molecular weight: 52533.44 Da
• Isoelectric Point: 4.7859

>T272274 WP_196731066.1 NZ_CP117798:3406887-3408257 [Proteus mirabilis]
MEKITLQAFLNQEWRDIAIINFPNDEHLALENQYDITYPITELAYESDYSIDYLFRDDHHAVSLNHPVSLFFDDKGSPGW
CKFLDDIVPSGASRRYWVQYLDIAGLSIAQQNYQLLRHGTISPIGNLRVKESLPHLSTLNNDLFFTIDEVKNRSSDFLEY
AQRKGAAAGGATGAGGEAPKLLLRCSHDEKIWIDTYQNDISNHDRYYLVKFPRGRRTSVDCNILRTEYAFYHELTAMGFN
TIPIEGMRLEEGDNYPSLWLPRFDIQIENNQVIRLAMESVYSILNKASGTTLYHEAVIREIIEKINQSNMVTEFGFQFNI
TNFIIEWVRRDLLNIIFGNSDNHGRNTSFIRKDNAIYLAPIYDFAPMKADPEGIVRTTKWQSYEMGGEFDFIGIANSLAD
LIPQEQLLEALRETALQLLDLKERLKERGVPEQILTMPTFGFDFIPDKLARWGLLP

Nucleotide

• Length: 1371 bp

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13542.07 Da
• Isoelectric Point: 10.6882

>AT272274 WP_060556489.1 NZ_CP117798:3408254-3408616 [Proteus mirabilis]
MNNIDNKITKLPLRASNNRSLIATIDRKKTIEKIMLSLLLEEISQGKALKILRLNILGLKQDAYAKLVNISRKTLSDIEN
DKGNYSIDIINKAFKPFGLKIGLVPATSHMLLSILKNHYQ

Nucleotide

• Length: 363 bp