272273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3231491..3232512 Replicon chromosome
Accession NZ_CP117798
Organism Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A8E4FRK4
Locus tag PT008_RS15515 Protein ID WP_017827532.1
Coordinates 3231943..3232512 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID B4F2H3
Locus tag PT008_RS15510 Protein ID WP_004245528.1
Coordinates 3231491..3231943 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT008_RS15490 (PT008_15490) 3227277..3227807 - 531 WP_004245524.1 RNA pyrophosphohydrolase -
PT008_RS15495 (PT008_15495) 3228124..3229089 + 966 WP_060557705.1 thiamine ABC transporter substrate binding subunit -
PT008_RS15500 (PT008_15500) 3229089..3230669 + 1581 WP_277697968.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
PT008_RS15505 (PT008_15505) 3230662..3231363 + 702 WP_004245527.1 thiamine ABC transporter ATP-binding protein ThiQ -
PT008_RS15510 (PT008_15510) 3231491..3231943 + 453 WP_004245528.1 helix-turn-helix domain-containing protein Antitoxin
PT008_RS15515 (PT008_15515) 3231943..3232512 + 570 WP_017827532.1 PIN domain-containing protein Toxin
PT008_RS15520 (PT008_15520) 3232628..3234982 + 2355 WP_277697969.1 DNA polymerase II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

SinI-like, DNA-binding domain

(80-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21601.08 Da        Isoelectric Point: 7.0180

>T272273 WP_017827532.1 NZ_CP117798:3231943-3232512 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKDPP
MTVETFLGCLQKQKLPQFISHLRAFQILL

Download         Length: 570 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16700.15 Da        Isoelectric Point: 5.7723

>AT272273 WP_004245528.1 NZ_CP117798:3231491-3231943 [Proteus mirabilis]
MNTISERLSAEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4F2H3

References