Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 2391719..2392464 Replicon chromosome
Accession NZ_CP117798
Organism Proteus mirabilis strain IVRI/FBI/326

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag PT008_RS11455 Protein ID WP_075673025.1
Coordinates 2391973..2392464 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag PT008_RS11450 Protein ID WP_075673024.1
Coordinates 2391719..2391985 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PT008_RS11415 (PT008_11415) 2387380..2387862 + 483 WP_277697860.1 flagellar basal body-associated protein FliL -
PT008_RS11420 (PT008_11420) 2387868..2388899 + 1032 WP_023581831.1 flagellar motor switch protein FliM -
PT008_RS11425 (PT008_11425) 2388892..2389302 + 411 WP_023581830.1 flagellar motor switch protein FliN -
PT008_RS11430 (PT008_11430) 2389306..2389752 + 447 WP_098942428.1 flagellar biosynthetic protein FliO -
PT008_RS11435 (PT008_11435) 2389752..2390522 + 771 WP_277697861.1 flagellar type III secretion system pore protein FliP -
PT008_RS11440 (PT008_11440) 2390538..2390807 + 270 WP_098942427.1 flagellar biosynthesis protein FliQ -
PT008_RS11445 (PT008_11445) 2390813..2391595 + 783 WP_098942426.1 flagellar biosynthetic protein FliR -
PT008_RS11450 (PT008_11450) 2391719..2391985 + 267 WP_075673024.1 DUF1778 domain-containing protein Antitoxin
PT008_RS11455 (PT008_11455) 2391973..2392464 + 492 WP_075673025.1 GNAT family N-acetyltransferase Toxin
PT008_RS11460 (PT008_11460) 2392550..2393494 - 945 WP_087802138.1 flagellar hook-associated protein FlgL -
PT008_RS11465 (PT008_11465) 2393519..2395162 - 1644 WP_098942424.1 flagellar hook-associated protein FlgK -
PT008_RS11470 (PT008_11470) 2395281..2396267 - 987 WP_099660621.1 flagellar assembly peptidoglycan hydrolase FlgJ -
PT008_RS11475 (PT008_11475) 2396267..2397373 - 1107 WP_098942422.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18228.15 Da        Isoelectric Point: 10.3194

>T272272 WP_075673025.1 NZ_CP117798:2391973-2392464 [Proteus mirabilis]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSTQDKILFLALK
KKI

Download         Length: 492 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10111.62 Da        Isoelectric Point: 4.5256

>AT272272 WP_075673024.1 NZ_CP117798:2391719-2391985 [Proteus mirabilis]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References