Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/PRK09907-MazE
Location 311834..312405 Replicon chromosome
Accession NZ_CP117797
Organism Fusobacterium nucleatum strain FNA

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PSR68_RS01520 Protein ID WP_273904759.1
Coordinates 312082..312405 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A140PUK7
Locus tag PSR68_RS01515 Protein ID WP_008701954.1
Coordinates 311834..312088 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR68_RS01500 (PSR68_01500) 307349..307768 - 420 WP_005910583.1 NfeD family protein -
PSR68_RS01505 (PSR68_01505) 308010..309479 + 1470 WP_158411227.1 N-acetylglucosamine-specific PTS transporter subunit IIBC -
PSR68_RS01510 (PSR68_01510) 309566..311632 + 2067 WP_273904756.1 elongation factor G -
PSR68_RS01515 (PSR68_01515) 311834..312088 + 255 WP_008701954.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PSR68_RS01520 (PSR68_01520) 312082..312405 + 324 WP_273904759.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PSR68_RS01525 (PSR68_01525) 312534..312818 - 285 WP_005910587.1 ferredoxin family protein -
PSR68_RS01530 (PSR68_01530) 312821..314116 - 1296 WP_273904760.1 FAD-dependent oxidoreductase -
PSR68_RS01535 (PSR68_01535) 314140..314835 - 696 WP_273904762.1 ubiquinone/menaquinone biosynthesis methyltransferase -
PSR68_RS01540 (PSR68_01540) 314837..315760 - 924 WP_273904764.1 prenyltransferase -
PSR68_RS01545 (PSR68_01545) 315757..316737 - 981 WP_273904765.1 polyprenyl synthetase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-106)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12410.48 Da        Isoelectric Point: 6.7218

>T272270 WP_273904759.1 NZ_CP117797:312082-312405 [Fusobacterium nucleatum]
VVERGDIIIINFDPVKGHEQAGKRPALVISNEKFYRIFKLAVILPITNNTKDFPFHVLLDDRTNIKGAILCEHLRTVDLE
ERKYNKVEKLPENLLEEVLEKVSLIFQ

Download         Length: 324 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 10117.64 Da        Isoelectric Point: 8.4038

>AT272270 WP_008701954.1 NZ_CP117797:311834-312088 [Fusobacterium nucleatum]
MEVLRVQKWGNSQGIRLPKKILKDLKIDINDKIEISLNGEEIILKKVKKYTSLDDLFKDYRGDYRKDFDEFEFFGEAQGR
EFKW

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A140PUK7

References