272267

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2494976..2495670 Replicon chromosome
Accession NZ_CP117782
Organism Burkholderia sp. FERM BP-3421

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Bsp3421_RS27255 Protein ID WP_273999093.1
Coordinates 2495497..2495670 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Bsp3421_RS27250 Protein ID WP_273999092.1
Coordinates 2494976..2495398 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Bsp3421_RS27235 (Bsp3421_005447) 2491903..2492190 + 288 WP_252982326.1 hypothetical protein -
Bsp3421_RS27240 (Bsp3421_005448) 2492400..2493923 + 1524 WP_273999090.1 threonine ammonia-lyase, biosynthetic -
Bsp3421_RS27245 (Bsp3421_005449) 2493938..2494762 + 825 WP_273999091.1 NADPH-dependent 7-cyano-7-deazaguanine reductase QueF -
Bsp3421_RS27250 (Bsp3421_005450) 2494976..2495398 - 423 WP_273999092.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Bsp3421_RS27255 (Bsp3421_005451) 2495497..2495670 - 174 WP_273999093.1 type II toxin-antitoxin system HicA family toxin Toxin
Bsp3421_RS27260 (Bsp3421_005452) 2496181..2496567 - 387 WP_273999095.1 Rid family hydrolase -
Bsp3421_RS27265 (Bsp3421_005453) 2496655..2498124 - 1470 WP_273999096.1 D-aminoacylase -
Bsp3421_RS27270 (Bsp3421_005454) 2498126..2499019 - 894 WP_273999097.1 MurR/RpiR family transcriptional regulator -
Bsp3421_RS27275 (Bsp3421_005455) 2499139..2500506 + 1368 WP_273999099.1 amino acid deaminase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-62)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6455.41 Da        Isoelectric Point: 10.8118

>T272267 WP_273999093.1 NZ_CP117782:c2495670-2495497 [Burkholderia sp. FERM BP-3421]
VKFSEFRRWLVDRGATFEEGAKHAKVYLNGRQTTLPRHSGEIGEGLRRAICKQLGLA

Download         Length: 174 bp

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15553.94 Da        Isoelectric Point: 4.6012

>AT272267 WP_273999092.1 NZ_CP117782:c2495398-2494976 [Burkholderia sp. FERM BP-3421]
MLRYPAKLERDGEGYVVTFRDIPEAITSGATKEEAWVMAEDALLTAMDFYIEDERVVPPPSGARRGEAFVELPASVSAKV
LLLNAMVDQSVRPFELAKRMGIRPQEVQRIMDLSHVTKIDTLEAAFAALGKRLEITAEAF

Download         Length: 423 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References