Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1502470..1504196 Replicon chromosome
Accession NZ_CP117781
Organism Burkholderia sp. FERM BP-3421

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag Bsp3421_RS09620 Protein ID WP_273995672.1
Coordinates 1502470..1503363 (+) Length 298 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag Bsp3421_RS09625 Protein ID WP_273995673.1
Coordinates 1503360..1504196 (+) Length 279 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Bsp3421_RS09590 (Bsp3421_001923) 1497888..1498964 - 1077 WP_273998262.1 porin -
Bsp3421_RS09595 (Bsp3421_001924) 1499390..1499707 + 318 WP_273998264.1 non-heme iron oxygenase ferredoxin subunit -
Bsp3421_RS09600 (Bsp3421_001925) 1499709..1500020 + 312 WP_273998266.1 hypothetical protein -
Bsp3421_RS09605 (Bsp3421_001926) 1500071..1501132 + 1062 WP_273998268.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
Bsp3421_RS09610 (Bsp3421_001927) 1501125..1501895 + 771 WP_273998269.1 SDR family oxidoreductase -
Bsp3421_RS09615 (Bsp3421_001928) 1501923..1502450 + 528 WP_273995671.1 cupin domain-containing protein -
Bsp3421_RS09620 (Bsp3421_001929) 1502470..1503363 + 894 WP_273995672.1 alpha/beta fold hydrolase Toxin
Bsp3421_RS09625 (Bsp3421_001930) 1503360..1504196 + 837 WP_273995673.1 IclR family transcriptional regulator Antitoxin
Bsp3421_RS09630 (Bsp3421_001931) 1504193..1504990 + 798 WP_273995674.1 SDR family oxidoreductase -
Bsp3421_RS09635 (Bsp3421_001932) 1504983..1506656 + 1674 WP_273995675.1 thiamine pyrophosphate-binding protein -
Bsp3421_RS09640 (Bsp3421_001933) 1506649..1507476 + 828 WP_273995676.1 aspartate dehydrogenase -
Bsp3421_RS09645 (Bsp3421_001934) 1507495..1508985 + 1491 WP_273995677.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-277)

Antitoxin

Transcription regulator IclR, N-terminal

(17-66)


Sequences

Toxin        


Download         Length: 298 a.a.        Molecular weight: 29939.34 Da        Isoelectric Point: 7.6662

>T272265 WP_273995672.1 NZ_CP117781:1502470-1503363 [Burkholderia sp. FERM BP-3421]
MSMIDTEPAGRDAVASFHARLACCPERRVQAGAAGVIGYREAGAAAGGLPVVLLHGIGSGAASWVRQLDALGAARRTLAW
DAPGYLASTPVSAASPLAADYAAALAAWLDALGIGRCVLVGHSLGALVAGGFARAWPGRLAGLLLLSPAGGYGAAPAELR
VARRDARLAMLAELGAQGLAARRSAAMLSAHAEPAAQDWVRWNMARIAPGGYAQATHLLANADLVADLGGFGGRVAVAVG
ALDTITPPAACERIAAAARVGLQVIPQVGHAGYVEAPNVYSALIDAFCRQCEGSEAA

Download         Length: 894 bp

Antitoxin


Download         Length: 279 a.a.        Molecular weight: 30486.00 Da        Isoelectric Point: 8.1000

>AT272265 WP_273995673.1 NZ_CP117781:1503360-1504196 [Burkholderia sp. FERM BP-3421]
MNEPRDAAEANYIVPGLERGLRLLAEFTPREPVLGAPELSKRLGIPRTTVFRLLQTLESMGFLERVDRDRNYRLGVAVLR
LGFEYLSSLELTDLGLPVIEGLREATGFTTHIVIRDGRDVVFVAKAQSLASAFSSVRVNAGTRLPAHATTHGHVLMGDLS
LDALRALYPEPRLERATPHTPTTVDALYALVRADAARGYGLSHSSFERGISVITAPVRNDTGKIAACLAVTVPRPEIDAT
LLADGLVDKVLRAAAELSRRLNYRSDEEHTYLKILGLR

Download         Length: 837 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References