Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4722091..4722667 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name shpA Uniprot ID A0A800YKM1
Locus tag PTC84_RS22845 Protein ID WP_015572580.1
Coordinates 4722091..4722378 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A801DSF4
Locus tag PTC84_RS22850 Protein ID WP_017694570.1
Coordinates 4722365..4722667 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS22820 (PTC84_22820) 4717208..4717903 + 696 WP_045348386.1 winged helix-turn-helix domain-containing protein -
PTC84_RS22825 (PTC84_22825) 4718053..4718523 + 471 WP_015572576.1 MarR family transcriptional regulator -
PTC84_RS22830 (PTC84_22830) 4718520..4719587 + 1068 WP_026080654.1 HlyD family secretion protein -
PTC84_RS22835 (PTC84_22835) 4719577..4720653 + 1077 WP_015572578.1 DUF2955 domain-containing protein -
PTC84_RS22840 (PTC84_22840) 4720650..4721921 - 1272 WP_251993402.1 DUF445 domain-containing protein -
PTC84_RS22845 (PTC84_22845) 4722091..4722378 + 288 WP_015572580.1 BrnT family toxin Toxin
PTC84_RS22850 (PTC84_22850) 4722365..4722667 + 303 WP_017694570.1 BrnA antitoxin family protein Antitoxin
PTC84_RS22855 (PTC84_22855) 4722696..4723334 - 639 WP_273961638.1 LysE family translocator -
PTC84_RS22860 (PTC84_22860) 4723373..4724125 - 753 WP_045348389.1 AraC family transcriptional regulator -
PTC84_RS22865 (PTC84_22865) 4724279..4725649 + 1371 WP_015572583.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PTC84_RS22870 (PTC84_22870) 4725829..4726374 - 546 WP_006810254.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11296.81 Da        Isoelectric Point: 7.3587

>T272253 WP_015572580.1 NZ_CP117750:4722091-4722378 [Enterobacter hormaechei]
MPIEYEWDSNKAKSNLQKHAIRFEDAVLVFDDPCHLSVQDRYENGEFRWQTIGLVQGVIVILVAHTVRFESGDEIIRIIS
ARKADRKERRRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11482.13 Da        Isoelectric Point: 10.4094

>AT272253 WP_017694570.1 NZ_CP117750:4722365-4722667 [Enterobacter hormaechei]
MSIVKHKRGSAPEVSARREAELKALADKPDREIDYSDIPATEDDRWAGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References