Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4409953..4410549 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PTC84_RS21355 Protein ID WP_023295756.1
Coordinates 4410247..4410549 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A927HL08
Locus tag PTC84_RS21350 Protein ID WP_023295755.1
Coordinates 4409953..4410240 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS21345 (PTC84_21345) 4408325..4409956 + 1632 WP_003860350.1 Na/Pi cotransporter family protein -
PTC84_RS21350 (PTC84_21350) 4409953..4410240 - 288 WP_023295755.1 putative addiction module antidote protein Antitoxin
PTC84_RS21355 (PTC84_21355) 4410247..4410549 - 303 WP_023295756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC84_RS21360 (PTC84_21360) 4410747..4411619 + 873 WP_003860347.1 23S rRNA pseudouridine(2604) synthase RluF -
PTC84_RS21365 (PTC84_21365) 4411620..4411892 - 273 WP_017382612.1 DUF3811 domain-containing protein -
PTC84_RS21370 (PTC84_21370) 4411943..4412887 - 945 WP_015570166.1 ketopantoate/pantoate/pantothenate transporter PanS -
PTC84_RS21375 (PTC84_21375) 4412981..4414330 - 1350 WP_006810501.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11441.24 Da        Isoelectric Point: 10.1042

>T272252 WP_023295756.1 NZ_CP117750:c4410549-4410247 [Enterobacter hormaechei]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDIRPVGEGISELRIHFGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNVSQWQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10101.59 Da        Isoelectric Point: 5.7807

>AT272252 WP_023295755.1 NZ_CP117750:c4410240-4409953 [Enterobacter hormaechei]
MHKLTPYDPANALLDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKPSGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References