Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4002136..4002752 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PTC84_RS19390 Protein ID WP_077266491.1
Coordinates 4002136..4002507 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PTC84_RS19395 Protein ID WP_196278329.1
Coordinates 4002510..4002752 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS19375 (PTC84_19375) 3999636..4000538 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
PTC84_RS19380 (PTC84_19380) 4000535..4001170 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
PTC84_RS19385 (PTC84_19385) 4001167..4002096 + 930 WP_003861956.1 formate dehydrogenase accessory protein FdhE -
PTC84_RS19390 (PTC84_19390) 4002136..4002507 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
PTC84_RS19395 (PTC84_19395) 4002510..4002752 - 243 WP_196278329.1 ribbon-helix-helix protein, CopG family Antitoxin
PTC84_RS19400 (PTC84_19400) 4002951..4003871 + 921 WP_032652004.1 alpha/beta hydrolase -
PTC84_RS19405 (PTC84_19405) 4003880..4004821 - 942 WP_015569910.1 fatty acid biosynthesis protein FabY -
PTC84_RS19410 (PTC84_19410) 4004866..4005303 - 438 WP_015569909.1 D-aminoacyl-tRNA deacylase -
PTC84_RS19415 (PTC84_19415) 4005300..4006181 - 882 WP_003861949.1 virulence factor BrkB family protein -
PTC84_RS19420 (PTC84_19420) 4006175..4006774 - 600 WP_003861947.1 glucose-1-phosphatase -
PTC84_RS19425 (PTC84_19425) 4006893..4007693 - 801 WP_003861944.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T272248 WP_077266491.1 NZ_CP117750:c4002507-4002136 [Enterobacter hormaechei]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9509.83 Da        Isoelectric Point: 4.5386

>AT272248 WP_196278329.1 NZ_CP117750:c4002752-4002510 [Enterobacter hormaechei]
MRVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References