Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3061256..3061913 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag PTC84_RS14855 Protein ID WP_017382887.1
Coordinates 3061256..3061666 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PTC84_RS14860 Protein ID WP_003863437.1
Coordinates 3061647..3061913 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS14835 (PTC84_14835) 3057254..3058987 - 1734 WP_196277555.1 single-stranded-DNA-specific exonuclease RecJ -
PTC84_RS14840 (PTC84_14840) 3058993..3059706 - 714 WP_023295380.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTC84_RS14845 (PTC84_14845) 3059735..3060631 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
PTC84_RS14850 (PTC84_14850) 3060733..3061254 + 522 WP_015571793.1 flavodoxin FldB -
PTC84_RS14855 (PTC84_14855) 3061256..3061666 - 411 WP_017382887.1 protein YgfX Toxin
PTC84_RS14860 (PTC84_14860) 3061647..3061913 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PTC84_RS14865 (PTC84_14865) 3062208..3063188 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
PTC84_RS14870 (PTC84_14870) 3063300..3063959 - 660 WP_003863433.1 hemolysin III family protein -
PTC84_RS14875 (PTC84_14875) 3064226..3064957 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
PTC84_RS14880 (PTC84_14880) 3065074..3066507 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T272247 WP_017382887.1 NZ_CP117750:c3061666-3061256 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT272247 WP_003863437.1 NZ_CP117750:c3061913-3061647 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References