Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1608137..1608876 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name tacT Uniprot ID A0A3L9PBP9
Locus tag PTC84_RS07920 Protein ID WP_003857133.1
Coordinates 1608137..1608622 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A837FCR9
Locus tag PTC84_RS07925 Protein ID WP_003857131.1
Coordinates 1608610..1608876 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS07890 (PTC84_07890) 1603401..1604159 + 759 WP_047637345.1 DeoR/GlpR family DNA-binding transcription regulator -
PTC84_RS07895 (PTC84_07895) 1604264..1605556 + 1293 WP_196278053.1 glycosyl hydrolase family 28 protein -
PTC84_RS07900 (PTC84_07900) 1605556..1606170 + 615 WP_080300286.1 NUDIX hydrolase -
PTC84_RS07905 (PTC84_07905) 1606354..1606989 - 636 WP_273961765.1 DUF421 domain-containing protein -
PTC84_RS07910 (PTC84_07910) 1606999..1607445 - 447 WP_273961766.1 DUF3290 domain-containing protein -
PTC84_RS07915 (PTC84_07915) 1607723..1607884 - 162 Protein_1551 ISNCY family transposase -
PTC84_RS07920 (PTC84_07920) 1608137..1608622 - 486 WP_003857133.1 GNAT family N-acetyltransferase Toxin
PTC84_RS07925 (PTC84_07925) 1608610..1608876 - 267 WP_003857131.1 DUF1778 domain-containing protein Antitoxin
PTC84_RS07930 (PTC84_07930) 1608940..1609869 - 930 WP_059294931.1 LysR family transcriptional regulator -
PTC84_RS07935 (PTC84_07935) 1609999..1611387 + 1389 WP_059294932.1 MFS transporter -
PTC84_RS07940 (PTC84_07940) 1611409..1612404 - 996 WP_015570513.1 DUF2891 domain-containing protein -
PTC84_RS07945 (PTC84_07945) 1612414..1613400 - 987 WP_063863964.1 DUF979 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1592977..1608876 15899


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(58-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17540.23 Da        Isoelectric Point: 9.9658

>T272241 WP_003857133.1 NZ_CP117750:c1608622-1608137 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILARLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT272241 WP_003857131.1 NZ_CP117750:c1608876-1608610 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3L9PBP9

Antitoxin

Source ID Structure
AlphaFold DB A0A837FCR9

References