Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 986076..986873 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag PTC84_RS04720 Protein ID WP_040117472.1
Coordinates 986352..986873 (+) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID F5RT92
Locus tag PTC84_RS04715 Protein ID WP_001303459.1
Coordinates 986076..986345 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS04680 (PTC84_04680) 981616..981975 + 360 WP_017384779.1 helix-turn-helix domain-containing protein -
PTC84_RS04685 (PTC84_04685) 982054..982149 - 96 Protein_911 transcriptional regulator -
PTC84_RS04690 (PTC84_04690) 982302..983543 + 1242 WP_017693667.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
PTC84_RS04695 (PTC84_04695) 983576..983803 - 228 WP_006809324.1 YccJ family protein -
PTC84_RS04700 (PTC84_04700) 983822..984418 - 597 WP_006809323.1 NAD(P)H:quinone oxidoreductase -
PTC84_RS04705 (PTC84_04705) 984810..984980 + 171 WP_001273664.1 general stress protein -
PTC84_RS04710 (PTC84_04710) 985097..986002 + 906 WP_017693666.1 DMT family transporter -
PTC84_RS04715 (PTC84_04715) 986076..986345 + 270 WP_001303459.1 DUF1778 domain-containing protein Antitoxin
PTC84_RS04720 (PTC84_04720) 986352..986873 + 522 WP_040117472.1 GNAT family N-acetyltransferase Toxin
PTC84_RS04725 (PTC84_04725) 986932..988254 - 1323 WP_196277966.1 pyrimidine utilization transport protein G -
PTC84_RS04730 (PTC84_04730) 988276..988767 - 492 WP_040117474.1 pyrimidine utilization flavin reductase protein F -
PTC84_RS04735 (PTC84_04735) 988780..989370 - 591 WP_040117475.1 malonic semialdehyde reductase -
PTC84_RS04740 (PTC84_04740) 989380..990180 - 801 WP_047735077.1 pyrimidine utilization protein D -
PTC84_RS04745 (PTC84_04745) 990188..990574 - 387 WP_040117477.1 pyrimidine utilization protein C -
PTC84_RS04750 (PTC84_04750) 990586..991275 - 690 WP_040117478.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-88)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19437.18 Da        Isoelectric Point: 7.4317

>T272240 WP_040117472.1 NZ_CP117750:986352-986873 [Enterobacter hormaechei]
VANLTIEMLSEGTDYDFGDFDCGEPSLNAFLTDHLVRQHGGRILRGYLLKERDHPRILGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKLGFIPLAGENSSSLF
FPTQSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10248.70 Da        Isoelectric Point: 5.8836

>AT272240 WP_001303459.1 NZ_CP117750:986076-986345 [Enterobacter hormaechei]
MPALKKQRIDLRLSDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7D7BCZ2

References