Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 336606..337226 Replicon chromosome
Accession NZ_CP117750
Organism Enterobacter hormaechei strain 2022CK-00700

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag PTC84_RS01555 Protein ID WP_015571250.1
Coordinates 336606..336824 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag PTC84_RS01560 Protein ID WP_006809850.1
Coordinates 336852..337226 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC84_RS01525 (PTC84_01525) 332618..332878 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
PTC84_RS01530 (PTC84_01530) 332881..333021 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PTC84_RS01535 (PTC84_01535) 333018..333728 - 711 WP_045344589.1 GNAT family protein -
PTC84_RS01540 (PTC84_01540) 333830..335290 + 1461 WP_045349927.1 PLP-dependent aminotransferase family protein -
PTC84_RS01545 (PTC84_01545) 335262..335729 - 468 WP_023296041.1 YlaC family protein -
PTC84_RS01550 (PTC84_01550) 335846..336397 - 552 WP_015571251.1 maltose O-acetyltransferase -
PTC84_RS01555 (PTC84_01555) 336606..336824 - 219 WP_015571250.1 HHA domain-containing protein Toxin
PTC84_RS01560 (PTC84_01560) 336852..337226 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
PTC84_RS01565 (PTC84_01565) 337737..340883 - 3147 WP_015571248.1 multidrug efflux RND transporter permease subunit AcrB -
PTC84_RS01570 (PTC84_01570) 340906..342099 - 1194 WP_017694395.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T272238 WP_015571250.1 NZ_CP117750:c336824-336606 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT272238 WP_006809850.1 NZ_CP117750:c337226-336852 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References