Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 5433444..5434030 Replicon chromosome
Accession NZ_CP117749
Organism Pseudomonas aeruginosa strain 2022CK-00828

Toxin (Protein)


Gene name PumA Uniprot ID G8CP73
Locus tag PTC91_RS25775 Protein ID WP_003120987.1
Coordinates 5433731..5434030 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag PTC91_RS25770 Protein ID WP_003448662.1
Coordinates 5433444..5433734 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC91_RS25750 (PTC91_25750) 5428595..5428804 + 210 WP_003105733.1 cold-shock protein -
PTC91_RS25755 (PTC91_25755) 5429026..5430915 + 1890 WP_016851610.1 hypothetical protein -
PTC91_RS25760 (PTC91_25760) 5430912..5432888 + 1977 WP_016851611.1 DEAD/DEAH box helicase -
PTC91_RS25765 (PTC91_25765) 5433029..5433373 + 345 WP_016851612.1 hypothetical protein -
PTC91_RS25770 (PTC91_25770) 5433444..5433734 - 291 WP_003448662.1 putative addiction module antidote protein Antitoxin
PTC91_RS25775 (PTC91_25775) 5433731..5434030 - 300 WP_003120987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC91_RS25780 (PTC91_25780) 5434232..5435356 + 1125 WP_012076859.1 TcpQ domain-containing protein -
PTC91_RS25785 (PTC91_25785) 5435356..5437065 + 1710 WP_012076860.1 PilN family type IVB pilus formation outer membrane protein -
PTC91_RS25790 (PTC91_25790) 5437069..5438394 + 1326 WP_003099758.1 type 4b pilus protein PilO2 -
PTC91_RS25795 (PTC91_25795) 5438384..5438917 + 534 WP_003099760.1 type IV pilus biogenesis protein PilP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 5406465..5494545 88080


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(47-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11133.88 Da        Isoelectric Point: 10.4495

>T272236 WP_003120987.1 NZ_CP117749:c5434030-5433731 [Pseudomonas aeruginosa]
MVEVKQTATFMAWESKLKDRRAKAVIAARIFRLANGLPGDVSPVGQGVSELRIHYGPGYRVYFQQRGTEIVILLCGGDKS
SQARDIEMAKRLANEWRPQ

Download         Length: 300 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.91 Da        Isoelectric Point: 4.7527

>AT272236 WP_003448662.1 NZ_CP117749:c5433734-5433444 [Pseudomonas aeruginosa]
MTEQIYDYDPAQALDSPEAMALFIADALDTGDTAYIAKAMGVVARAKGMTELAKETGLAREQLYKSFSERGNPTLKTMLA
VMRALGVDLTARPHAQ

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8CP73

Antitoxin

Source ID Structure

References