272235

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5006734..5007342 Replicon chromosome
Accession NZ_CP117749
Organism Pseudomonas aeruginosa strain 2022CK-00828

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag PTC91_RS23785 Protein ID WP_019486378.1
Coordinates 5006734..5007081 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag PTC91_RS23790 Protein ID WP_003114155.1
Coordinates 5007091..5007342 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC91_RS23760 (PTC91_23760) 5001796..5002128 + 333 WP_003121550.1 IS66 family insertion sequence element accessory protein TnpB -
PTC91_RS23765 (PTC91_23765) 5002205..5003755 + 1551 WP_151023681.1 IS66 family transposase -
PTC91_RS23770 (PTC91_23770) 5003778..5004197 - 420 WP_151023680.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
PTC91_RS23775 (PTC91_23775) 5004394..5005353 + 960 WP_228846185.1 cation transporter -
PTC91_RS23780 (PTC91_23780) 5005516..5006424 + 909 WP_003141085.1 LysR family transcriptional regulator -
PTC91_RS23785 (PTC91_23785) 5006734..5007081 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC91_RS23790 (PTC91_23790) 5007091..5007342 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTC91_RS23795 (PTC91_23795) 5007556..5008539 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
PTC91_RS23800 (PTC91_23800) 5008539..5009831 - 1293 WP_003115206.1 hypothetical protein -
PTC91_RS23805 (PTC91_23805) 5010090..5011352 - 1263 WP_019486376.1 zonular occludens toxin domain-containing protein -
PTC91_RS23810 (PTC91_23810) 5011354..5011704 - 351 WP_003133726.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4879877..5047579 167702
- flank IS/Tn - - 5001766..5002128 362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T272235 WP_019486378.1 NZ_CP117749:c5007081-5006734 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT272235 WP_003114155.1 NZ_CP117749:c5007342-5007091 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References