272234

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4538768..4540026 Replicon chromosome
Accession NZ_CP117749
Organism Pseudomonas aeruginosa strain 2022CK-00828

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag PTC91_RS21440 Protein ID WP_003086331.1
Coordinates 4538768..4539523 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag PTC91_RS21445 Protein ID WP_003086329.1
Coordinates 4539658..4540026 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC91_RS21430 (PTC91_21430) 4533936..4536479 + 2544 WP_019486194.1 acyl-homoserine-lactone acylase QuiP -
PTC91_RS21435 (PTC91_21435) 4536634..4537995 - 1362 WP_003134034.1 DNA recombination protein RmuC -
PTC91_RS21440 (PTC91_21440) 4538768..4539523 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
PTC91_RS21445 (PTC91_21445) 4539658..4540026 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
PTC91_RS21450 (PTC91_21450) 4540099..4541385 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
PTC91_RS21455 (PTC91_21455) 4541441..4542934 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
PTC91_RS21460 (PTC91_21460) 4543109..4543585 + 477 WP_019486191.1 elongation factor GreAB -
PTC91_RS21465 (PTC91_21465) 4543588..4543863 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T272234 WP_003086331.1 NZ_CP117749:c4539523-4538768 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT272234 WP_003086329.1 NZ_CP117749:c4540026-4539658 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References