Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 3532885..3534106 | Replicon | chromosome |
Accession | NZ_CP117749 | ||
Organism | Pseudomonas aeruginosa strain 2022CK-00828 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A0H2Z8V4 |
Locus tag | PTC91_RS16595 | Protein ID | WP_003110488.1 |
Coordinates | 3533528..3534106 (+) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | - |
Locus tag | PTC91_RS16590 | Protein ID | WP_003088112.1 |
Coordinates | 3532885..3533439 (+) | Length | 185 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
PTC91_RS16565 (PTC91_16565) | 3528453..3529004 | + | 552 | WP_019485487.1 | XRE family transcriptional regulator | - |
PTC91_RS16570 (PTC91_16570) | 3529001..3529399 | - | 399 | WP_019485486.1 | NADH-quinone oxidoreductase subunit A | - |
PTC91_RS16575 (PTC91_16575) | 3529412..3529735 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
PTC91_RS16580 (PTC91_16580) | 3530066..3530527 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
PTC91_RS16585 (PTC91_16585) | 3530532..3532727 | + | 2196 | WP_023091929.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
PTC91_RS16590 (PTC91_16590) | 3532885..3533439 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
PTC91_RS16595 (PTC91_16595) | 3533528..3534106 | + | 579 | WP_003110488.1 | HD domain-containing protein | Toxin |
PTC91_RS16600 (PTC91_16600) | 3534216..3535403 | - | 1188 | WP_003110489.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
PTC91_RS16605 (PTC91_16605) | 3535393..3537564 | - | 2172 | WP_003088105.1 | type I secretion system permease/ATPase | - |
PTC91_RS16610 (PTC91_16610) | 3537554..3538831 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21913.75 Da Isoelectric Point: 5.3655
>T272233 WP_003110488.1 NZ_CP117749:3533528-3534106 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT272233 WP_003088112.1 NZ_CP117749:3532885-3533439 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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