Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3532885..3534106 Replicon chromosome
Accession NZ_CP117749
Organism Pseudomonas aeruginosa strain 2022CK-00828

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PTC91_RS16595 Protein ID WP_003110488.1
Coordinates 3533528..3534106 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PTC91_RS16590 Protein ID WP_003088112.1
Coordinates 3532885..3533439 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC91_RS16565 (PTC91_16565) 3528453..3529004 + 552 WP_019485487.1 XRE family transcriptional regulator -
PTC91_RS16570 (PTC91_16570) 3529001..3529399 - 399 WP_019485486.1 NADH-quinone oxidoreductase subunit A -
PTC91_RS16575 (PTC91_16575) 3529412..3529735 - 324 WP_003102734.1 multidrug efflux SMR transporter -
PTC91_RS16580 (PTC91_16580) 3530066..3530527 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PTC91_RS16585 (PTC91_16585) 3530532..3532727 + 2196 WP_023091929.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PTC91_RS16590 (PTC91_16590) 3532885..3533439 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
PTC91_RS16595 (PTC91_16595) 3533528..3534106 + 579 WP_003110488.1 HD domain-containing protein Toxin
PTC91_RS16600 (PTC91_16600) 3534216..3535403 - 1188 WP_003110489.1 HlyD family efflux transporter periplasmic adaptor subunit -
PTC91_RS16605 (PTC91_16605) 3535393..3537564 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
PTC91_RS16610 (PTC91_16610) 3537554..3538831 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T272233 WP_003110488.1 NZ_CP117749:3533528-3534106 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT272233 WP_003088112.1 NZ_CP117749:3532885-3533439 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References