Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150986..151491 Replicon chromosome
Accession NZ_CP117749
Organism Pseudomonas aeruginosa strain 2022CK-00828

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PTC91_RS00705 Protein ID WP_003083773.1
Coordinates 150986..151267 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PTC91_RS00710 Protein ID WP_003083775.1
Coordinates 151264..151491 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC91_RS00680 (PTC91_00680) 146237..147586 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
PTC91_RS00685 (PTC91_00685) 147635..148321 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
PTC91_RS00690 (PTC91_00690) 148422..149156 + 735 WP_003110658.1 GntR family transcriptional regulator -
PTC91_RS00695 (PTC91_00695) 149336..149746 + 411 WP_003110659.1 aegerolysin family protein -
PTC91_RS00700 (PTC91_00700) 149778..150686 - 909 WP_003083769.1 LysR family transcriptional regulator -
PTC91_RS00705 (PTC91_00705) 150986..151267 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PTC91_RS00710 (PTC91_00710) 151264..151491 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PTC91_RS00715 (PTC91_00715) 151667..152290 - 624 WP_003137011.1 hypothetical protein -
PTC91_RS00720 (PTC91_00720) 152391..152891 + 501 WP_003101228.1 LEA type 2 family protein -
PTC91_RS00725 (PTC91_00725) 152963..153304 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
PTC91_RS00730 (PTC91_00730) 153386..154813 - 1428 WP_003083784.1 GABA permease -
PTC91_RS00735 (PTC91_00735) 154982..156475 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T272230 WP_003083773.1 NZ_CP117749:c151267-150986 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT272230 WP_003083775.1 NZ_CP117749:c151491-151264 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References