Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 180646..181556 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP117746 | ||
| Organism | Klebsiella pneumoniae strain 2022CK-00752 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | PTC85_RS27475 | Protein ID | WP_004026354.1 |
| Coordinates | 181086..181556 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | PTC85_RS27470 | Protein ID | WP_004026357.1 |
| Coordinates | 180646..181089 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PTC85_RS27455 (PTC85_27455) | 177280..178767 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| PTC85_RS27460 (PTC85_27460) | 178853..179275 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| PTC85_RS27465 (PTC85_27465) | 179275..180546 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| PTC85_RS27470 (PTC85_27470) | 180646..181089 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| PTC85_RS27475 (PTC85_27475) | 181086..181556 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| PTC85_RS27480 (PTC85_27480) | 181665..181925 | - | 261 | WP_004026352.1 | hypothetical protein | - |
| PTC85_RS27485 (PTC85_27485) | 182648..182806 | + | 159 | WP_004181898.1 | type I toxin-antitoxin system Hok family toxin | - |
| PTC85_RS27495 (PTC85_27495) | 184118..184570 | + | 453 | Protein_195 | CatA-like O-acetyltransferase | - |
| PTC85_RS27500 (PTC85_27500) | 184771..185148 | - | 378 | WP_000656305.1 | GNAT family N-acetyltransferase | - |
| PTC85_RS27505 (PTC85_27505) | 185459..186463 | - | 1005 | WP_000427619.1 | IS110-like element IS5075 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / blaNDM-5 / aph(3')-VI / qnrS1 / blaCTX-M-15 / mph(A) / sul1 / qacE / dfrA5 | iucA / iucB / iucC / iucD / iutA / rmpA2 | 1..381441 | 381441 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T272228 WP_004026354.1 NZ_CP117746:181086-181556 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT272228 WP_004026357.1 NZ_CP117746:180646-181089 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |