272227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 24095..24617 Replicon plasmid unnamed1
Accession NZ_CP117746
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag PTC85_RS26655 Protein ID WP_004181778.1
Coordinates 24333..24617 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag PTC85_RS26650 Protein ID WP_025368601.1
Coordinates 24095..24343 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS26630 (PTC85_26630) 19304..20125 - 822 WP_004026535.1 hypothetical protein -
PTC85_RS26635 (PTC85_26635) 20187..20540 - 354 WP_004181774.1 hypothetical protein -
PTC85_RS26640 (PTC85_26640) 20685..21671 - 987 WP_025368599.1 hypothetical protein -
PTC85_RS26645 (PTC85_26645) 22005..23804 - 1800 WP_025368600.1 ATP-dependent helicase -
PTC85_RS26650 (PTC85_26650) 24095..24343 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTC85_RS26655 (PTC85_26655) 24333..24617 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC85_RS26660 (PTC85_26660) 24847..26073 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
PTC85_RS26665 (PTC85_26665) 26359..26784 - 426 WP_040120489.1 IS200/IS605 family transposase -
PTC85_RS26670 (PTC85_26670) 26821..28047 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
PTC85_RS26675 (PTC85_26675) 28113..29239 - 1127 Protein_31 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1A / blaOXA-9 / ant(3'')-Ia / aac(6')-Ib / blaNDM-5 / aph(3')-VI / qnrS1 / blaCTX-M-15 / mph(A) / sul1 / qacE / dfrA5 iucA / iucB / iucC / iucD / iutA / rmpA2 1..381441 381441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T272227 WP_004181778.1 NZ_CP117746:24333-24617 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT272227 WP_025368601.1 NZ_CP117746:24095-24343 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References