Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5006092..5007773 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name mosT Uniprot ID A6TH06
Locus tag PTC85_RS24580 Protein ID WP_015959269.1
Coordinates 5006092..5006967 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag PTC85_RS24585 Protein ID WP_004177809.1
Coordinates 5007015..5007773 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS24560 (5001398) 5001398..5002918 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
PTC85_RS24565 (5002915) 5002915..5003913 + 999 WP_002885172.1 ribose ABC transporter permease -
PTC85_RS24570 (5003944) 5003944..5004885 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
PTC85_RS24575 (5004960) 5004960..5005967 + 1008 WP_015959270.1 carbohydrate kinase family protein -
PTC85_RS24580 (5006092) 5006092..5006967 - 876 WP_015959269.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PTC85_RS24585 (5007015) 5007015..5007773 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PTC85_RS24590 (5007859) 5007859..5008587 - 729 WP_032413197.1 response regulator transcription factor -
PTC85_RS24595 (5008860) 5008860..5011007 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
PTC85_RS24600 (5011004) 5011004..5011147 - 144 WP_162897205.1 hypothetical protein -
PTC85_RS24605 (5011585) 5011585..5012271 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(7-264)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 32990.17 Da        Isoelectric Point: 5.4637

>T272225 WP_015959269.1 NZ_CP117745:c5006967-5006092 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 876 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT272225 WP_004177809.1 NZ_CP117745:c5007773-5007015 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TH06

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References