Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4846353..4846869 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag PTC85_RS23765 Protein ID WP_009486548.1
Coordinates 4846353..4846637 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PTC85_RS23770 Protein ID WP_002886901.1
Coordinates 4846627..4846869 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS23740 (4841770) 4841770..4842033 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
PTC85_RS23745 (4842163) 4842163..4842336 + 174 WP_032433782.1 hypothetical protein -
PTC85_RS23750 (4842339) 4842339..4843082 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PTC85_RS23755 (4843439) 4843439..4845577 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PTC85_RS23760 (4845885) 4845885..4846349 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PTC85_RS23765 (4846353) 4846353..4846637 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC85_RS23770 (4846627) 4846627..4846869 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PTC85_RS23775 (4846947) 4846947..4848857 - 1911 WP_009486549.1 PRD domain-containing protein -
PTC85_RS23780 (4848880) 4848880..4850034 - 1155 WP_002886900.1 lactonase family protein -
PTC85_RS23785 (4850101) 4850101..4850841 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T272224 WP_009486548.1 NZ_CP117745:c4846637-4846353 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT272224 WP_002886901.1 NZ_CP117745:c4846869-4846627 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References