Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2738969..2740557 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag PTC85_RS13490 Protein ID WP_002904792.1
Coordinates 2738969..2740291 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PTC85_RS13495 Protein ID WP_002904790.1
Coordinates 2740291..2740557 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS13475 (2734025) 2734025..2736526 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
PTC85_RS13480 (2736514) 2736514..2737518 + 1005 WP_032433097.1 fimbrial protein -
PTC85_RS13485 (2737660) 2737660..2738952 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PTC85_RS13490 (2738969) 2738969..2740291 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
PTC85_RS13495 (2740291) 2740291..2740557 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PTC85_RS13500 (2740943) 2740943..2741269 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PTC85_RS13505 (2741266) 2741266..2741766 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PTC85_RS13510 (2741744) 2741744..2743123 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
PTC85_RS13515 (2743469) 2743469..2744623 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PTC85_RS13520 (2744604) 2744604..2745527 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T272221 WP_002904792.1 NZ_CP117745:c2740291-2738969 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT272221 WP_002904790.1 NZ_CP117745:c2740557-2740291 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References