272216

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1472604..1473340 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag PTC85_RS07280 Protein ID WP_032433360.1
Coordinates 1472858..1473340 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag PTC85_RS07275 Protein ID WP_003026799.1
Coordinates 1472604..1472870 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS07250 (1468250) 1468250..1469389 + 1140 WP_032433368.1 mannitol dehydrogenase -
PTC85_RS07255 (1469418) 1469418..1470080 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
PTC85_RS07260 (1470064) 1470064..1471068 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
PTC85_RS07265 (1471086) 1471086..1471718 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
PTC85_RS07270 (1471728) 1471728..1472291 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
PTC85_RS07275 (1472604) 1472604..1472870 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
PTC85_RS07280 (1472858) 1472858..1473340 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
PTC85_RS07285 (1473540) 1473540..1474943 + 1404 WP_001272054.1 ISNCY-like element ISKpn21 family transposase -
PTC85_RS07290 (1474972) 1474972..1475604 - 633 WP_001567369.1 hypothetical protein -
PTC85_RS07295 (1475984) 1475984..1476583 - 600 WP_064472304.1 helix-turn-helix transcriptional regulator -
PTC85_RS07300 (1476796) 1476796..1477740 - 945 WP_077254249.1 fimbrial protein -
PTC85_RS07305 (1477752) 1477752..1478330 - 579 WP_032432061.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1440549..1486566 46017
- flank IS/Tn - - 1473540..1474943 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T272216 WP_032433360.1 NZ_CP117745:1472858-1473340 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT272216 WP_003026799.1 NZ_CP117745:1472604-1472870 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References