Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1455913..1456556 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag PTC85_RS07185 Protein ID WP_032433387.1
Coordinates 1456140..1456556 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q6U620
Locus tag PTC85_RS07180 Protein ID WP_004213073.1
Coordinates 1455913..1456143 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS07165 (1450935) 1450935..1452022 + 1088 Protein_1398 transcriptional repressor PifC -
PTC85_RS07170 (1452025) 1452025..1454265 + 2241 WP_045326788.1 P-loop NTPase fold protein -
PTC85_RS07175 (1454793) 1454793..1455608 - 816 WP_032433388.1 hypothetical protein -
PTC85_RS07180 (1455913) 1455913..1456143 + 231 WP_004213073.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PTC85_RS07185 (1456140) 1456140..1456556 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
PTC85_RS07190 (1456712) 1456712..1457692 + 981 WP_032433385.1 hypothetical protein -
PTC85_RS07195 (1457887) 1457887..1459458 - 1572 WP_032433383.1 AAA family ATPase -
PTC85_RS07200 (1459777) 1459777..1460025 + 249 WP_032433382.1 hypothetical protein -
PTC85_RS07205 (1460084) 1460084..1460602 + 519 WP_045326794.1 hypothetical protein -
PTC85_RS07210 (1460633) 1460633..1461124 + 492 WP_032433378.1 hypothetical protein -
PTC85_RS07215 (1461184) 1461184..1461387 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1440549..1486566 46017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T272215 WP_032433387.1 NZ_CP117745:1456140-1456556 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.73 Da        Isoelectric Point: 4.4563

>AT272215 WP_004213073.1 NZ_CP117745:1455913-1456143 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRAAPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB Q6U620

References