Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837536..838193 Replicon chromosome
Accession NZ_CP117745
Organism Klebsiella pneumoniae strain 2022CK-00752

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag PTC85_RS04200 Protein ID WP_002916310.1
Coordinates 837783..838193 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PTC85_RS04195 Protein ID WP_002916312.1
Coordinates 837536..837802 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC85_RS04170 (832692) 832692..834125 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
PTC85_RS04175 (834244) 834244..834972 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
PTC85_RS04180 (835022) 835022..835333 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PTC85_RS04185 (835497) 835497..836156 + 660 WP_002916317.1 hemolysin III family protein -
PTC85_RS04190 (836307) 836307..837290 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
PTC85_RS04195 (837536) 837536..837802 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PTC85_RS04200 (837783) 837783..838193 + 411 WP_002916310.1 protein YgfX Toxin
PTC85_RS04205 (838200) 838200..838721 - 522 WP_004144730.1 flavodoxin FldB -
PTC85_RS04210 (838822) 838822..839718 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PTC85_RS04215 (839741) 839741..840454 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTC85_RS04220 (840460) 840460..842193 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T272214 WP_002916310.1 NZ_CP117745:837783-838193 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT272214 WP_002916312.1 NZ_CP117745:837536-837802 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References