Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 142166..143076 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP117741 | ||
| Organism | Klebsiella pneumoniae strain 2022CK-00768 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A663AYG0 |
| Locus tag | PTC88_RS27255 | Protein ID | WP_004026354.1 |
| Coordinates | 142606..143076 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | PTC88_RS27250 | Protein ID | WP_004026357.1 |
| Coordinates | 142166..142609 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PTC88_RS27235 (PTC88_27235) | 138800..140287 | + | 1488 | WP_004178082.1 | group II intron reverse transcriptase/maturase | - |
| PTC88_RS27240 (PTC88_27240) | 140373..140795 | + | 423 | WP_004181893.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
| PTC88_RS27245 (PTC88_27245) | 140795..142066 | + | 1272 | WP_004181894.1 | translesion error-prone DNA polymerase V subunit UmuC | - |
| PTC88_RS27250 (PTC88_27250) | 142166..142609 | + | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| PTC88_RS27255 (PTC88_27255) | 142606..143076 | + | 471 | WP_004026354.1 | RES family NAD+ phosphorylase | Toxin |
| PTC88_RS27265 (PTC88_27265) | 144154..144606 | + | 453 | Protein_154 | CatA-like O-acetyltransferase | - |
| PTC88_RS27270 (PTC88_27270) | 144807..145184 | - | 378 | WP_000656305.1 | GNAT family N-acetyltransferase | - |
| PTC88_RS27275 (PTC88_27275) | 145495..146499 | - | 1005 | WP_000427619.1 | IS110-like element IS5075 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaNDM-5 / aph(3')-VI / qnrS1 / blaCTX-M-15 / mph(A) / sul1 / qacE / dfrA5 | iucA / iucB / iucC / iucD / iutA / rmpA | 1..341460 | 341460 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17515.79 Da Isoelectric Point: 4.6155
>T272210 WP_004026354.1 NZ_CP117741:142606-143076 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT272210 WP_004026357.1 NZ_CP117741:142166-142609 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AYG0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |