Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 22940..23462 Replicon plasmid unnamed1
Accession NZ_CP117741
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name stbE Uniprot ID A0A2J4R0S6
Locus tag PTC88_RS26625 Protein ID WP_004181778.1
Coordinates 23178..23462 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5Q9LM53
Locus tag PTC88_RS26620 Protein ID WP_025368601.1
Coordinates 22940..23188 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS26600 (PTC88_26600) 18149..18970 - 822 WP_004026535.1 hypothetical protein -
PTC88_RS26605 (PTC88_26605) 19032..19385 - 354 WP_004181774.1 hypothetical protein -
PTC88_RS26610 (PTC88_26610) 19530..20516 - 987 WP_025368599.1 hypothetical protein -
PTC88_RS26615 (PTC88_26615) 20850..22649 - 1800 WP_025368600.1 ATP-dependent helicase -
PTC88_RS26620 (PTC88_26620) 22940..23188 + 249 WP_025368601.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTC88_RS26625 (PTC88_26625) 23178..23462 + 285 WP_004181778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC88_RS26630 (PTC88_26630) 23692..24918 + 1227 WP_025368602.1 RNA-guided endonuclease TnpB family protein -
PTC88_RS26635 (PTC88_26635) 25204..25629 - 426 WP_040120489.1 IS200/IS605 family transposase -
PTC88_RS26640 (PTC88_26640) 25666..26892 + 1227 WP_025368604.1 RNA-guided endonuclease TnpB family protein -
PTC88_RS26645 (PTC88_26645) 26941..28070 - 1130 Protein_30 conjugal transfer protein TraG N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaNDM-5 / aph(3')-VI / qnrS1 / blaCTX-M-15 / mph(A) / sul1 / qacE / dfrA5 iucA / iucB / iucC / iucD / iutA / rmpA 1..341460 341460


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10970.69 Da        Isoelectric Point: 10.6516

>T272209 WP_004181778.1 NZ_CP117741:23178-23462 [Klebsiella pneumoniae]
MTYKLAFNESALKEWKKLGHTIREQFKKKLAERLLNPRVPASQLHGRKDQYKIKLRGAGYRLVYSVNDDVVTVTVIGVGK
RENDDIYNLTKHRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8906.12 Da        Isoelectric Point: 3.8206

>AT272209 WP_025368601.1 NZ_CP117741:22940-23188 [Klebsiella pneumoniae]
MAFQVLTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAQLMELLEDQELGHIADERIGEAVIEVSLD
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4R0S6

Antitoxin

Source ID Structure
AlphaFold DB A0A5Q9LM53

References