Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4997891..4999572 Replicon chromosome
Accession NZ_CP117740
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name mosT Uniprot ID A6TH06
Locus tag PTC88_RS24555 Protein ID WP_015959269.1
Coordinates 4997891..4998766 (-) Length 292 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag PTC88_RS24560 Protein ID WP_004177809.1
Coordinates 4998814..4999572 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS24535 (4993197) 4993197..4994717 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
PTC88_RS24540 (4994714) 4994714..4995712 + 999 WP_002885172.1 ribose ABC transporter permease -
PTC88_RS24545 (4995743) 4995743..4996684 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
PTC88_RS24550 (4996759) 4996759..4997766 + 1008 WP_015959270.1 carbohydrate kinase family protein -
PTC88_RS24555 (4997891) 4997891..4998766 - 876 WP_015959269.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
PTC88_RS24560 (4998814) 4998814..4999572 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
PTC88_RS24565 (4999658) 4999658..5000386 - 729 WP_032413197.1 response regulator transcription factor -
PTC88_RS24570 (5000659) 5000659..5002806 + 2148 WP_012737173.1 formate dehydrogenase H subunit alpha, selenocysteine-containing -
PTC88_RS24575 (5002803) 5002803..5002946 - 144 WP_162897205.1 hypothetical protein -
PTC88_RS24580 (5003384) 5003384..5004070 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(7-264)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 292 a.a.        Molecular weight: 32990.17 Da        Isoelectric Point: 5.4637

>T272207 WP_015959269.1 NZ_CP117740:c4998766-4997891 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 876 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT272207 WP_004177809.1 NZ_CP117740:c4999572-4998814 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6TH06

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References