Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4838152..4838668 Replicon chromosome
Accession NZ_CP117740
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag PTC88_RS23740 Protein ID WP_009486548.1
Coordinates 4838152..4838436 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag PTC88_RS23745 Protein ID WP_002886901.1
Coordinates 4838426..4838668 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS23715 (4833569) 4833569..4833832 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
PTC88_RS23720 (4833962) 4833962..4834135 + 174 WP_032433782.1 hypothetical protein -
PTC88_RS23725 (4834138) 4834138..4834881 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
PTC88_RS23730 (4835238) 4835238..4837376 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
PTC88_RS23735 (4837684) 4837684..4838148 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PTC88_RS23740 (4838152) 4838152..4838436 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC88_RS23745 (4838426) 4838426..4838668 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PTC88_RS23750 (4838746) 4838746..4840656 - 1911 WP_009486549.1 PRD domain-containing protein -
PTC88_RS23755 (4840679) 4840679..4841833 - 1155 WP_002886900.1 lactonase family protein -
PTC88_RS23760 (4841900) 4841900..4842640 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T272206 WP_009486548.1 NZ_CP117740:c4838436-4838152 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT272206 WP_002886901.1 NZ_CP117740:c4838668-4838426 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References