Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2730766..2732354 Replicon chromosome
Accession NZ_CP117740
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag PTC88_RS13460 Protein ID WP_002904792.1
Coordinates 2730766..2732088 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag PTC88_RS13465 Protein ID WP_002904790.1
Coordinates 2732088..2732354 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS13445 (2725822) 2725822..2728323 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
PTC88_RS13450 (2728311) 2728311..2729315 + 1005 WP_032433097.1 fimbrial protein -
PTC88_RS13455 (2729457) 2729457..2730749 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
PTC88_RS13460 (2730766) 2730766..2732088 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
PTC88_RS13465 (2732088) 2732088..2732354 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PTC88_RS13470 (2732740) 2732740..2733066 - 327 WP_002904788.1 hydroxyisourate hydrolase -
PTC88_RS13475 (2733063) 2733063..2733563 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
PTC88_RS13480 (2733541) 2733541..2734920 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
PTC88_RS13485 (2735266) 2735266..2736420 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
PTC88_RS13490 (2736401) 2736401..2737324 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T272203 WP_002904792.1 NZ_CP117740:c2732088-2730766 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT272203 WP_002904790.1 NZ_CP117740:c2732354-2732088 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References