Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1469546..1470282 Replicon chromosome
Accession NZ_CP117740
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag PTC88_RS07275 Protein ID WP_032433360.1
Coordinates 1469800..1470282 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag PTC88_RS07270 Protein ID WP_003026799.1
Coordinates 1469546..1469812 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS07245 (1465192) 1465192..1466331 + 1140 WP_032433368.1 mannitol dehydrogenase -
PTC88_RS07250 (1466360) 1466360..1467022 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
PTC88_RS07255 (1467006) 1467006..1468010 + 1005 WP_032433364.1 dihydroxyacetone kinase subunit DhaK -
PTC88_RS07260 (1468028) 1468028..1468660 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
PTC88_RS07265 (1468670) 1468670..1469233 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
PTC88_RS07270 (1469546) 1469546..1469812 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
PTC88_RS07275 (1469800) 1469800..1470282 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
PTC88_RS07280 (1470482) 1470482..1471885 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
PTC88_RS07285 (1471914) 1471914..1472546 - 633 WP_001567369.1 hypothetical protein -
PTC88_RS07290 (1472926) 1472926..1473525 - 600 WP_064472304.1 helix-turn-helix transcriptional regulator -
PTC88_RS07295 (1473738) 1473738..1474682 - 945 WP_077254249.1 fimbrial protein -
PTC88_RS07300 (1474694) 1474694..1475272 - 579 WP_032432061.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1437491..1483508 46017
- flank IS/Tn - - 1470482..1471885 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T272198 WP_032433360.1 NZ_CP117740:1469800-1470282 [Klebsiella pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT272198 WP_003026799.1 NZ_CP117740:1469546-1469812 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References