Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1452855..1453498 Replicon chromosome
Accession NZ_CP117740
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag PTC88_RS07180 Protein ID WP_032433387.1
Coordinates 1453082..1453498 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag PTC88_RS07175 Protein ID WP_001261276.1
Coordinates 1452855..1453085 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS07160 (1447877) 1447877..1448964 + 1088 Protein_1397 transcriptional repressor PifC -
PTC88_RS07165 (1448967) 1448967..1451207 + 2241 WP_045326788.1 P-loop NTPase fold protein -
PTC88_RS07170 (1451735) 1451735..1452550 - 816 WP_032433388.1 hypothetical protein -
PTC88_RS07175 (1452855) 1452855..1453085 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PTC88_RS07180 (1453082) 1453082..1453498 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
PTC88_RS07185 (1453654) 1453654..1454634 + 981 WP_032433385.1 hypothetical protein -
PTC88_RS07190 (1454829) 1454829..1456400 - 1572 WP_032433383.1 AAA family ATPase -
PTC88_RS07195 (1456719) 1456719..1456967 + 249 WP_032433382.1 hypothetical protein -
PTC88_RS07200 (1457026) 1457026..1457544 + 519 WP_045326794.1 hypothetical protein -
PTC88_RS07205 (1457575) 1457575..1458066 + 492 WP_032433378.1 hypothetical protein -
PTC88_RS07210 (1458126) 1458126..1458329 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1437491..1483508 46017


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T272197 WP_032433387.1 NZ_CP117740:1453082-1453498 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT272197 WP_001261276.1 NZ_CP117740:1452855-1453085 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References