Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835626..836283 Replicon chromosome
Accession NZ_CP117740
Organism Klebsiella pneumoniae strain 2022CK-00768

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag PTC88_RS04195 Protein ID WP_002916310.1
Coordinates 835873..836283 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag PTC88_RS04190 Protein ID WP_002916312.1
Coordinates 835626..835892 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC88_RS04165 (830782) 830782..832215 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
PTC88_RS04170 (832334) 832334..833062 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
PTC88_RS04175 (833112) 833112..833423 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
PTC88_RS04180 (833587) 833587..834246 + 660 WP_002916317.1 hemolysin III family protein -
PTC88_RS04185 (834397) 834397..835380 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
PTC88_RS04190 (835626) 835626..835892 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
PTC88_RS04195 (835873) 835873..836283 + 411 WP_002916310.1 protein YgfX Toxin
PTC88_RS04200 (836290) 836290..836811 - 522 WP_004144730.1 flavodoxin FldB -
PTC88_RS04205 (836912) 836912..837808 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
PTC88_RS04210 (837831) 837831..838544 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTC88_RS04215 (838550) 838550..840283 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T272196 WP_002916310.1 NZ_CP117740:835873-836283 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT272196 WP_002916312.1 NZ_CP117740:835626-835892 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References