Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 156979..157550 Replicon plasmid unnamed2
Accession NZ_CP117732
Organism Klebsiella grimontii strain 2022CK-00781

Toxin (Protein)


Gene name parE Uniprot ID A0A2I8S8S5
Locus tag PTC90_RS30510 Protein ID WP_011918375.1
Coordinates 156979..157290 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Z3MW28
Locus tag PTC90_RS30515 Protein ID WP_011787805.1
Coordinates 157290..157550 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC90_RS30500 (PTC90_30495) 152976..153827 + 852 WP_273863395.1 3'-5' exonuclease -
PTC90_RS30505 (PTC90_30500) 153875..156955 - 3081 WP_011787830.1 Tn3 family transposase -
PTC90_RS30510 (PTC90_30505) 156979..157290 - 312 WP_011918375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC90_RS30515 (PTC90_30510) 157290..157550 - 261 WP_011787805.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PTC90_RS30520 (PTC90_30515) 157720..158340 + 621 WP_011787804.1 recombinase family protein -
PTC90_RS30525 (PTC90_30520) 158458..158790 - 333 WP_011787803.1 TraR/DksA C4-type zinc finger protein -
PTC90_RS30530 (PTC90_30525) 158881..159738 - 858 WP_055329964.1 universal stress protein -
PTC90_RS30535 (PTC90_30530) 159773..161263 - 1491 WP_011787801.1 SulP family inorganic anion transporter -
PTC90_RS30540 (PTC90_30535) 161758..162078 + 321 Protein_184 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaFOX-5 / blaCARB-2 / aadA2 / cmlA1 / qacE / sul1 / dfrA19 / ant(2'')-Ia / msr(E) - 1..178660 178660


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-61)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11862.70 Da        Isoelectric Point: 8.5341

>T272193 WP_011918375.1 NZ_CP117732:c157290-156979 [Klebsiella grimontii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRMNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9312.71 Da        Isoelectric Point: 6.4546

>AT272193 WP_011787805.1 NZ_CP117732:c157550-157290 [Klebsiella grimontii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAITDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S8S5

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z3MW28

References