Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5846101..5846711 Replicon chromosome
Accession NZ_CP117730
Organism Klebsiella grimontii strain 2022CK-00781

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PTC90_RS28065 Protein ID WP_024360704.1
Coordinates 5846101..5846475 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PTC90_RS28070 Protein ID WP_077253475.1
Coordinates 5846472..5846711 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC90_RS28050 (PTC90_28045) 5843256..5844158 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
PTC90_RS28055 (PTC90_28050) 5844155..5844790 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
PTC90_RS28060 (PTC90_28055) 5845134..5846063 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
PTC90_RS28065 (PTC90_28060) 5846101..5846475 - 375 WP_024360704.1 type II toxin-antitoxin system VapC family toxin Toxin
PTC90_RS28070 (PTC90_28065) 5846472..5846711 - 240 WP_077253475.1 CopG family transcriptional regulator Antitoxin
PTC90_RS28075 (PTC90_28070) 5846917..5847834 + 918 WP_024360706.1 alpha/beta hydrolase -
PTC90_RS28080 (PTC90_28075) 5847852..5848793 - 942 WP_004127112.1 fatty acid biosynthesis protein FabY -
PTC90_RS28085 (PTC90_28080) 5848838..5849275 - 438 WP_004132870.1 D-aminoacyl-tRNA deacylase -
PTC90_RS28090 (PTC90_28085) 5849272..5850132 - 861 WP_024360708.1 virulence factor BrkB family protein -
PTC90_RS28095 (PTC90_28090) 5850126..5850725 - 600 WP_024360709.1 glucose-1-phosphatase -
PTC90_RS28100 (PTC90_28095) 5850855..5851640 - 786 WP_064342034.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14127.49 Da        Isoelectric Point: 8.4571

>T272190 WP_024360704.1 NZ_CP117730:c5846475-5846101 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITLYHL

Download         Length: 375 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT272190 WP_077253475.1 NZ_CP117730:c5846711-5846472 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References