Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1050..1642 Replicon plasmid unnamed3
Accession NZ_CP117726
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag PTC87_RS23900 Protein ID WP_000520549.1
Coordinates 1050..1298 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag PTC87_RS23905 Protein ID WP_000681613.1
Coordinates 1295..1642 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS23890 (PTC87_23890) 5..304 + 300 WP_000650309.1 hypothetical protein -
PTC87_RS23895 (PTC87_23895) 395..745 + 351 WP_000854259.1 hypothetical protein -
PTC87_RS23900 (PTC87_23900) 1050..1298 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
PTC87_RS23905 (PTC87_23905) 1295..1642 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PTC87_RS23910 (PTC87_23910) 2005..2508 + 504 WP_000781817.1 DNA distortion polypeptide 1 -
PTC87_RS23915 (PTC87_23915) 2512..3741 + 1230 WP_001329504.1 DNA relaxase/nickase TaxC -
PTC87_RS23920 (PTC87_23920) 3818..4111 + 294 WP_000134733.1 sigma factor-like helix-turn-helix DNA-binding protein -
PTC87_RS23925 (PTC87_23925) 4108..4323 + 216 WP_053897400.1 EexN family lipoprotein -
PTC87_RS23930 (PTC87_23930) 4680..5300 + 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
PTC87_RS23935 (PTC87_23935) 5314..5640 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..32938 32938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T272177 WP_000520549.1 NZ_CP117726:1050-1298 [Enterobacter asburiae]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT272177 WP_000681613.1 NZ_CP117726:1295-1642 [Enterobacter asburiae]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References