Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4664293..4664909 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PTC87_RS22315 Protein ID WP_080277799.1
Coordinates 4664293..4664664 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PTC87_RS22320 Protein ID WP_033146961.1
Coordinates 4664667..4664909 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS22300 (PTC87_22300) 4661793..4662695 + 903 WP_010436855.1 formate dehydrogenase subunit beta -
PTC87_RS22305 (PTC87_22305) 4662692..4663327 + 636 WP_010436852.1 formate dehydrogenase cytochrome b556 subunit -
PTC87_RS22310 (PTC87_22310) 4663324..4664253 + 930 WP_023309751.1 formate dehydrogenase accessory protein FdhE -
PTC87_RS22315 (PTC87_22315) 4664293..4664664 - 372 WP_080277799.1 type II toxin-antitoxin system VapC family toxin Toxin
PTC87_RS22320 (PTC87_22320) 4664667..4664909 - 243 WP_033146961.1 CopG family transcriptional regulator Antitoxin
PTC87_RS22325 (PTC87_22325) 4665109..4666029 + 921 WP_033146962.1 alpha/beta hydrolase -
PTC87_RS22330 (PTC87_22330) 4666038..4666979 - 942 WP_033146963.1 fatty acid biosynthesis protein FabY -
PTC87_RS22335 (PTC87_22335) 4667024..4667461 - 438 WP_033146964.1 D-aminoacyl-tRNA deacylase -
PTC87_RS22340 (PTC87_22340) 4667458..4668339 - 882 WP_033146965.1 virulence factor BrkB family protein -
PTC87_RS22345 (PTC87_22345) 4668333..4668932 - 600 WP_033146966.1 glucose-1-phosphatase -
PTC87_RS22350 (PTC87_22350) 4669021..4669491 - 471 WP_033146967.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13687.90 Da        Isoelectric Point: 6.9789

>T272174 WP_080277799.1 NZ_CP117723:c4664664-4664293 [Enterobacter asburiae]
MEHMAVFDTNILIDLFNNRVEAADAIDRTASHRAISLITWMEVMVGARKHGHEAKTATVMGVFEIIDITRDIAERSVILR
EKHGMKLPDAIILATAQSRSCPLISRNTKDFLGITGVVSPYQL

Download         Length: 372 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9469.67 Da        Isoelectric Point: 4.2917

>AT272174 WP_033146961.1 NZ_CP117723:c4664909-4664667 [Enterobacter asburiae]
MILSADLDMGRILIDLSEDVIQRLDNLKQLRNRPRAELLREAIEQYLDQQSSSVIRDALGLWGNQQEDGLEYERKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References